Although hydrogels are promising transdermal patches, they face spatiotemporal problems related to controlled drug release. From the “spatio” perspective, hydrogels are not malleable, therefore they do not fully contact curved skin, such as that found on the nose and fingers. From the “temporal” perspective, the internal network of a hydrogel retards cargo release. Herein, a malleable and rapid‐cargo‐releasing poly(vinyl alcohol)‐borax hydrogel that embeds freely mobile poly(hydroxyethyl methacrylate) (PHEMA) micelles is prepared. The in situ polymerization of PHEMA within the matrix produces large compound micelle particles that are not bound by the matrix. The micelles act as expellers by sweeping out cargo upon exposure to wet conditions through a concentration gradient. The hydrogel embedded with the micellar cargo‐expellers delivers a 25‐fold larger 3‐min release quantity of Nile Red (a model cargo) than the control hydrogel. The particles absorb mechanical shocks and the dynamic borate‐diol bonds engender the hydrogel with self‐healing properties, which results in a hydrogel that tightly contacts highly curved skin. Moreover, the hydrogel shows no toxicity in in vivo and skin irritation tests. This malleable hydrogel will inspire novel prompt skin‐patch systems for pharmaceutical and cosmetics purposes.

中文翻译：

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嵌入了胶束货物推进器的可延展水凝胶，作为一种及时的透皮贴剂。

尽管水凝胶是有希望的透皮贴剂，但它们面临与药物控制释放相关的时空问题。从“空间”的角度来看，水凝胶是不可延展的，因此它们不能完全接触弯曲的皮肤，例如鼻子和手指上的皮肤。从“时间”的角度来看，水凝胶的内部网络会延迟货物的释放。在此，制备了可延展且可快速释放的聚乙烯醇-硼砂水凝胶，其中嵌入了可自由移动的聚甲基丙烯酸羟乙酯（PHEMA）胶束。基质内PHEMA的原位聚合产生了未被基质束缚的大化合物胶束颗粒。胶束通过暴露于潮湿条件下通过浓度梯度将货物扫出而充当推进器。嵌入胶束货物推进器的水凝胶可比对照水凝胶提供3分钟的尼罗红（模型货物）释放量大25倍。颗粒吸收机械冲击，动态的硼酸酯-二醇键使水凝胶具有自愈特性，从而使水凝胶紧密接触高度弯曲的皮肤。此外，该水凝胶在体内和皮肤刺激试验中均未显示毒性。这种可延展的水凝胶将激发出新颖的，用于制药和化妆品目的的快速皮肤修补系统。水凝胶在体内和皮肤刺激性试验中均未显示毒性。这种可延展的水凝胶将激发出新颖的，用于制药和化妆品目的的快速皮肤修补系统。水凝胶在体内和皮肤刺激性试验中均未显示毒性。这种可延展的水凝胶将激发出新颖的，用于制药和化妆品目的的快速皮肤修补系统。