Binge eating disorder (BED) is known as the most common eating disorder with both psychosocial and biological factors involved. In this regard, there is a need to recognize probable disturbances in substances involved in food intake regulation in BED. In this study, we hypothesized that the levels of endocannabinoids, fatty acid amid hydrolase (FAAH) gene polymorphisms, and appetite regulatory substances are different in overweight and obese women with and without BED. A Binge Eating Scale was used to estimate the prevalence of BED in 180 women classified as overweight or obese. The levels of anandamide (AEA), 2-arachidonoylglycerol (2-AG), leptin, insulin, and orexin-A were measured by enzyme-linked immunosorbent assay kits. The subjects were genotyped for polymorphisms of FAAH gene using amplification refractory mutation system-polymerase chain reaction. Data were analyzed using SPSS software. About 41.6% (n = 75) of the subjects were diagnosed with BED. Women with BED exhibited significantly higher levels of AEA, 2-AG, leptin, and insulin compared to non-BED women (P < .05). Binary logistic regression analysis also showed that AEA, leptin, and insulin were the predictors of having BED after adjusting for body mass index (P < .05). In addition, the frequency of A allele of FAAH gene was higher in women with BED compared to women without BED; however, there were no significant differences between these 2 groups (P = .08). These results supported our hypothesis in the cases of AEA, 2-AG, leptin, and insulin but not orexin and FAAH gene polymorphisms. The findings of the current study provide further evidence concerning the role of these substances in BED.

中文翻译：

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有和没有暴食症女性的内源性大麻素水平、FAAH 基因多态性和食欲调节物质的比较：一项横断面研究

暴食症 (BED) 被认为是最常见的饮食失调症，涉及社会心理和生物因素。在这方面，有必要识别 BED 中与食物摄入调节相关的物质的可能干扰。在这项研究中，我们假设有和没有 BED 的超重和肥胖女性的内源性大麻素、脂肪酸酰胺水解酶 (FAAH) 基因多态性和食欲调节物质的水平不同。暴食量表用于估计 180 名被归类为超重或肥胖的女性的 BED 患病率。通过酶联免疫吸附测定试剂盒测量 anandamide (AEA)、2-花生四烯酸甘油 (2-AG)、瘦素、胰岛素和食欲素-A 的水平。使用扩增难治性突变系统-聚合酶链反应对受试者进行FAAH基因多态性基因分型。使用SPSS软件对数据进行分析。大约 41.6% (n = 75) 的受试者被诊断为 BED。与非 BED 女性相比，BED​​ 女性的 AEA、2-AG、瘦素和胰岛素水平显着更高（P < .05）。二元逻辑回归分析还表明，在调整体重指数后，AEA、瘦素和胰岛素是 BED 的预测因素（P < .05）。此外，与没有BED的女性相比，BED​​女性FAAH基因A等位基因的频率更高；然而，这两组之间没有显着差异（P = .08）。这些结果支持我们在 AEA、2-AG、瘦素和胰岛素的情况下的假设，但不支持食欲素和 FAAH 基因多态性。