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Single Cell Technologies Define New Therapeutic Avenues for Huntington's Disease.
Neuron ( IF 16.2 ) Pub Date : 2020-09-09 , DOI: 10.1016/j.neuron.2020.08.007 Tamara Maiuri 1 , Ray Truant 1
中文翻译:
单细胞技术为亨廷顿氏病定义了新的治疗途径。
更新日期:2020-09-10
Neuron ( IF 16.2 ) Pub Date : 2020-09-09 , DOI: 10.1016/j.neuron.2020.08.007 Tamara Maiuri 1 , Ray Truant 1
Affiliation
Using two independent single-cell transcriptomics technologies, Lee et al. have cataloged transcriptional changes in the subset of striatal neurons hit hardest in Huntington’s disease. One downregulated pathway, oxidative phosphorylation, may also explain their observed release of mitochondrial-encoded RNAs.
中文翻译:
单细胞技术为亨廷顿氏病定义了新的治疗途径。
Lee等人使用两种独立的单细胞转录组学技术。在亨廷顿舞蹈病中受打击最严重的纹状体神经元亚群中,已列出了转录变化。一种被下调的途径,氧化磷酸化,也可能解释了它们观察到的线粒体编码RNA的释放。