Guillain-Barré syndrome (GBS) is an immune-mediated paralytic disorder. Glucocorticoid receptor (GR) gene polymorphisms affect the sensitivity to glucocorticoids and have been related to microbial colonization and infection, and thereby may influence susceptibility to GBS. The associations between GR polymorphisms (ER22/23EK, N363S, BclI, TthIII-1 and GR-9beta) and development of GBS were investigated in 151 patients and 151 healthy controls. GR polymorphisms or haplotypes were not associated with GBS susceptibility. Haplotype 1 (TthIII-1[T/T]:BclI[G/G]:GR-9beta[A/A]) was less common in GBS; but not statistically significant after correction (P = 0.021; Pc = 0.108). The GR-9beta(G/A) and TthIII-1(C/T) genotypes were frequent in anti-GM1-antibody-positive patients than anti-GM1-antibody-negative patients (P = 0.017 and P = 0.030, respectively).

中文翻译：

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吉兰-巴雷综合征糖皮质激素受体基因多态性

格林-巴利综合征 (GBS) 是一种免疫介导的麻痹性疾病。糖皮质激素受体 (GR) 基因多态性影响对糖皮质激素的敏感性，并与微生物定植和感染有关，从而可能影响对 GBS 的易感性。在 151 名患者和 151 名健康对照者中调查了 GR 多态性（ER22/23EK、N363S、BclI、TthIII-1 和 GR-9beta）与 GBS 发展之间的关联。GR 多态性或单倍型与 GBS 易感性无关。单倍型 1 (TthIII-1[T/T]:BclI[G/G]:GR-9beta[A/A]) 在 GBS 中不太常见；但校正后无统计学意义（P = 0.021；Pc = 0.108）。GR-9beta(G/A) 和 TthIII-1(C/T) 基因型在抗 GM1 抗体阳性患者中比抗 GM1 抗体阴性患者更常见（分别为 P = 0.017 和 P = 0.030） .