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Deep brain stimulation of terminating axons
Brain Stimulation ( IF 7.7 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.brs.2020.09.001
Kelsey L Bower 1 , Cameron C McIntyre 1
Affiliation  

BACKGROUND Deep brain stimulation (DBS) of the subthalamic region is an established treatment for the motor symptoms of Parkinson's disease. Several types of neural elements reside in the subthalamic region, including subthalamic nucleus (STN) neurons, fibers of passage, and terminating afferents. Recent studies suggest that direct activation of a specific population of subthalamic afferents, known as the hyperdirect pathway, may be responsible for some of the therapeutic effects of subthalamic DBS. OBJECTIVE The goal of this study was to quantify how axon termination affects neural excitability from DBS. We evaluated how adjusting different stimulation parameters influenced the relative excitability of terminating axons (TAs) compared to fibers of passage (FOPs). METHODS We used finite element electric field models of DBS, coupled to multi-compartment cable models of axons, to calculate activation thresholds for populations of TAs and FOPs. These generalized models were used to evaluate the response to anodic vs. cathodic stimulation, with short vs. long stimulus pulses. RESULTS Terminating axons generally exhibited lower thresholds than fibers of passage across all tested parameters. Short pulse widths accentuated the relative excitability of TAs over FOPs. CONCLUSION(S) Our computational results demonstrate a hyperexcitability of terminating axons to DBS that is robust to variation in the stimulation parameters, as well as the axon model parameters.

中文翻译:

终止轴突的深部脑刺激

背景下丘脑区域的深部脑刺激(DBS)是帕金森病运动症状的既定治疗方法。几种类型的神经元件位于丘脑底区域,包括丘脑底核 (STN) 神经元、通道纤维和终止传入。最近的研究表明,被称为超直接通路的特定丘脑下传入神经群的直接激活可能是丘脑下 DBS 的一些治疗效果的原因。目的 本研究的目的是量化轴突终止如何影响 DBS 的神经兴奋性。我们评估了与通道纤维 (FOP) 相比,调整不同刺激参数如何影响终止轴突 (TA) 的相对兴奋性。方法 我们使用 DBS 的有限元电场模型,耦合到轴突的多室电缆模型,以计算 TA 和 FOP 种群的激活阈值。这些通用模型用于评估对阳极刺激与阴极刺激的响应,具有短刺激脉冲与长刺激脉冲。结果 在所有测试参数中,终止轴突的阈值通常低于通道纤维。短脉冲宽度强调了 TA 相对于 FOP 的相对兴奋性。结论(S)我们的计算结果证明了终止轴突到 DBS 的过度兴奋性,它对刺激参数以及轴突模型参数的变化具有鲁棒性。长刺激脉冲。结果 在所有测试参数中,终止轴突的阈值通常低于通道纤维。短脉冲宽度强调了 TA 相对于 FOP 的相对兴奋性。结论(S)我们的计算结果证明了终止轴突到 DBS 的过度兴奋性,它对刺激参数以及轴突模型参数的变化具有鲁棒性。长刺激脉冲。结果 在所有测试参数中,终止轴突的阈值通常低于通道纤维。短脉冲宽度强调了 TA 相对于 FOP 的相对兴奋性。结论(S)我们的计算结果证明了终止轴突到 DBS 的过度兴奋性,它对刺激参数以及轴突模型参数的变化具有鲁棒性。
更新日期:2020-11-01
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