Abstract

New water-soluble copper(II) bis-N,O-chelate complexes [Cu(L²)₂Cl₂] (I), [Cu₂(L¹)₂Cl₄] (II), and [Cu(L¹)₂Cl]₂[CuCl₄] (III) (L¹, L² = pyridyl-containing phospholane oxides) were prepared from N,O-ligands. The complexes were characterized by physicochemical methods (mass spectrometry, IR spectroscopy, elemental analysis, and X-ray diffraction (CIF files CCDC nos. 1976723 (I), 1976724 (II), and 1974303 (III)). The physicochemical properties of the products were studied and the molecular and crystal structures were established. The cytotoxicity against M-HeLa cancer cell lines and Chang liver normal cell lines was determined for the binuclear complex [Cu₂(L¹)₂Cl₄].

中文翻译：

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含吡啶基氧化膦氧化物的N，O杂配体铜（II）配合物

摘要

新型水溶性铜（II）双-N，O螯合物[Cu（L ²）₂ Cl ₂ ]（I），[Cu ₂（L ¹）₂ Cl ₄ ]（II）和[Cu（L ¹）₂ CL] ₂ [的CuCl ₄ ]（III）（L ¹，L ² =吡啶基含磷杂环戊烷氧化物）选自N，O配体来制备。通过理化方法（质谱，红外光谱，元素分析和X射线衍射（CIF文件，CCDC号1976723（I），1976724（II）和1974303（III））。研究了产品的理化性质，建立了分子和晶体结构。确定了双核复合物[Cu ₂（L ¹）₂ Cl ₄ ]对M-HeLa癌细胞系和长肝正常细胞系的细胞毒性。