Abstract The Zinc finger antiviral proteins (ZAP) are expressed by the cells in response to different viral attacks. The ZAP marks the viral mRNA for degradation with the help of different cellular proteins for exosome. Beside the degradation of viral mRNA, the ZAP protein also inihibits translation of proteins from this mRNA. Although it is not a universal antiviral protein, but a number of important human pathogenic viruses are controlled by the ZAP protein. In this review article we have discussed the current progress made in understanding the structure, function, mechanism and therapeutic roles of the ZAP protein.

中文翻译：

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锌指抗病毒蛋白在病毒免疫中的作用

摘要 锌指抗病毒蛋白 (ZAP) 由细胞表达，以响应不同的病毒攻击。ZAP 在外泌体的不同细胞蛋白的帮助下标记病毒 mRNA 进行降解。除了病毒 mRNA 的降解外，ZAP 蛋白还抑制来自该 mRNA 的蛋白质的翻译。虽然它不是一种通用的抗病毒蛋白，但许多重要的人类致病病毒都是由 ZAP 蛋白控制的。在这篇综述文章中，我们讨论了目前在理解 ZAP 蛋白的结构、功能、机制和治疗作用方面取得的进展。