Gibberella ear rot (GER) caused by Fusarium graminearum (teleomorph Gibberella zeae), is one of the most devastating diseases in maize that not only severely reduces grain yield but also contaminates the kernels with potent mycotoxins which is harmful to livestock and humans. Identification of stable quantitative trait loci (QTL) and candidate genes conferring resistance is a promising strategy in resistance breeding programs for the disease. Here, the ten times intermated B73 × Mo17-doubled haploid (IBM Syn10 DH) population comprising a total of 298 diverse maize inbred lines were subjected to phenotypic evaluation in a 2-year field test across two environments, and the IBM Syn10 DH population were employed to detect QTL across multiple environments using an ultra-high-density bin map. Ten QTL were detected on chromosomes 1, 2, 3, 6, 7, 8, and 9, respectively. Of them, a major QTL on chromosome 7, named qGRfg7, could explain 33.26% of the phenotypic variation. Based on fine-mapping strategy, we narrowed down the interested region into 91 kb, flanked by two developed Indel markers. A predicted gene in the mapped region, encoding a lipopolysaccharide-binding protein (LBP), is suggested to be a candidate gene conferring resistance to GER disease. These results will facilitate the breeding process for GER resistance by marker-assisted selection (MAS) in maize.

赤引起穗腐病（GER）禾谷镰刀菌（有性型玉米赤霉）是玉米中最毁灭性的疾病之一，不仅严重降低了谷物的产量，而且还用有效的霉菌毒素污染了玉米粒，霉菌毒素对牲畜和人类均有害。稳定的数量性状基因座（QTL）和候选基因的抗性鉴定是该病抗性育种计划中的一项有前途的策略。在这里，在两个环境中进行了为期2年的田间试验，对十次测定的B73×Mo17双倍单倍体（IBM Syn10 DH）群体（总共298个玉米自交系）进行了表型评估，并进行了2年的实地测试。用于使用超高密度bin图跨多个环境检测QTL。分别在1、2、3、6、7、8和9号染色体上检测到十个QTL。其中，第7号染色体上的主要QTL名为qGRfg7可以解释33.26％的表型变异。基于精细映射策略，我们将感兴趣的区域缩小为91 kb，两侧是两个发达的Indel标记。建议在映射区域中编码脂多糖结合蛋白（LBP）的预测基因是赋予对GER病抗性的候选基因。这些结果将通过标记辅助选择（MAS）在玉米中促进抗GER的育种过程。