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Analysis of indigenous plasmid sequences of A. baumannii DS002 reveals the existence of lateral mobility and extensive genetic recombination among Acinetobacter plasmids
Journal of Genetics ( IF 1.5 ) Pub Date : 2020-09-09 , DOI: 10.1007/s12041-020-01232-8
Devyani Samantarrai , Harshita Yakkala , Dayananda Siddavattam

Genome sequence of Acinetobacter baumannii DS002 revealed the existence of seven contigs with features of indigenous plasmids. Of the seven contigs, three of them have shown size and sequence identity. They appeared to have been generated due to the unique recombination events leading to a large-scale recombination and sequence inversions. The rest of the indigenous plasmids have shown significant size variations and contained the genetic repertoire required for the detoxification of formaldehyde and biosynthesis of exopolysaccharides. Genetic modules encoding novel toxin–antitoxin systems were found in most of the plasmids to ensure their survival in the host. In some instances, the toxin and antitoxin coding sequences were found on two different plasmids promoting the cosegregation of these two plasmids into the daughter cells.

中文翻译:

鲍曼不动杆菌 DS002 本地质粒序列分析揭示不动杆菌质粒之间存在横向迁移和广泛的基因重组

鲍曼不动杆菌 DS002 的基因组序列显示存在七个具有本地质粒特征的重叠群。在七个重叠群中,其中三个显示了大小和序列同一性。它们似乎是由于导致大规模重组和序列倒置的独特重组事件而产生的。其余的本地质粒显示出显着的大小变化,并包含甲醛解毒和胞外多糖生物合成所需的基因库。在大多数质粒中发现了编码新型毒素-抗毒素系统的遗传模块,以确保它们在宿主中的存活。在某些情况下,在两种不同的质粒上发现了毒素和抗毒素编码序列,促进了这两种质粒共分离到子细胞中。
更新日期:2020-09-09
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