MiR-548 has been reported to be involved in a variety of tumor processes, but its function in breast cancer remains unclear. In this study, we found that miR-548 was low expressed in breast cancer tissues and cells compared with normal control. We then examined whether up-regulation of miR-548 could improve the progression of breast cancer. Our results indicate that up-regulation of miR-548 significantly inhibits cell proliferation, migration andinvasion, and induces apoptosis in breast cancer cells. Further studies showed that miR-548 could specifically inhibit E2F3 expression. Moreover, rescue test showed that up-regulation of E2F2 could reverse the effect of miR-548 on proliferation, migration, invasion and apoptosis of breast cancer cells. In general, miR-548 could improve the progression of breast cancer. By targeting E2F2, which may make a potential target for the treatment of breast cancer.

据报道，MiR-548 参与多种肿瘤过程，但其在乳腺癌中的功能尚不清楚。在本研究中，我们发现与正常对照相比，miR-548 在乳腺癌组织和细胞中的表达较低。然后我们检查了 miR-548 的上调是否可以改善乳腺癌的进展。我们的结果表明 miR-548 的上调显着抑制细胞增殖、迁移和侵袭，并诱导乳腺癌细胞凋亡。进一步的研究表明，miR-548 可以特异性抑制 E2F3 的表达。此外，救援试验表明，E2F2的上调可以逆转miR-548对乳腺癌细胞增殖、迁移、侵袭和凋亡的影响。总的来说，miR-548可以改善乳腺癌的进展。通过针对 E2F2，