The Hanahan and Weinberg “hallmarks of cancer” papers provide a useful structure for considering the various mechanisms driving cancer progression, and the same might be useful for wound healing. In this Review, we highlight how tissue repair and cancer share cellular and molecular processes that are regulated in a wound but misregulated in cancer. From sustained proliferative signaling and the activation of invasion and angiogenesis to the promoting role of inflammation, there are many obvious parallels through which one process can inform the other. For some hallmarks, the parallels are more obscure. We propose some new prospective hallmarks that might apply to both cancer and wound healing and discuss how wounding, as in biopsy and surgery, might positively or negatively influence cancer in the clinic.

Hanahan 和 Weinberg 的“癌症标志”论文提供了一个有用的结构来考虑驱动癌症进展的各种机制，同样可能对伤口愈合有用。在这篇综述中，我们重点介绍了组织修复和癌症如何共享在伤口中受调节但在癌症中失控的细胞和分子过程。从持续的增殖信号、侵袭和血管生成的激活到炎症的促进作用，一个过程可以通过许多明显的相似之处来通知另一个。对于某些标志，相似之处更加模糊。我们提出了一些可能适用于癌症和伤口愈合的新的前瞻性标志，并讨论了活检和手术中的伤口如何对临床中的癌症产生积极或消极的影响。