Open Biology ( IF 5.8 ) Pub Date : 2020-09-09 , DOI: 10.1098/rsob.200174 Ravikant Piyush 1 , Keshav Rajarshi 2 , Rajni Khan 3 , Shashikant Ray 4
The world is passing through a very difficult phase due to the coronavirus disease 2019 (COVID-19) pandemic, which has disrupted almost all spheres of life. Globally, according to the latest World Health Organization report (10 August 2020), COVID-19 has affected nearly 20 million lives, causing 728 013 deaths. Due to the lack of specific therapeutic drugs and vaccines, the outbreak of disease has spawned a corpus of contagious infection all over the world, day by day, without control. As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a very rapid infection rate, it is essential to develop a novel ameliorative and curative strategy as quickly as possible. Convalescent plasma (CP) therapy is a type of adaptive immunity that has already been found to be effective in confronting several infectious diseases from the last two decades. For example, CP therapy was used in the treatment of viral-induced diseases like SARS-CoV epidemics, Middle East respiratory syndrome coronavirus (MERS-CoV) pandemics, Ebola epidemics and H1N1 pandemic. In this review, we have mainly focused on the therapeutic role of CP therapy and its neutralizing effect to fight against the COVID-19 outbreak.
中文翻译:
恢复期血浆疗法:一种有前途的 2019 年冠状病毒病治疗策略。
由于 2019 年冠状病毒病 (COVID-19) 大流行,世界正在经历一个非常困难的阶段,它扰乱了几乎所有生活领域。在全球范围内,根据世界卫生组织最新报告(2020 年 8 月 10 日),COVID-19 已影响近 2000 万人的生命,导致 728,013 人死亡。由于缺乏特效治疗药物和疫苗,疾病的爆发在世界各地催生了传染源,日复一日,无法控制。由于严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的感染率非常快,因此必须尽快开发新的改善和治疗策略。恢复期血浆(CP)疗法是一种适应性免疫,在过去二十年中已被发现可有效对抗多种传染病。例如,CP疗法用于治疗病毒引起的疾病,如SARS-CoV流行病、中东呼吸综合征冠状病毒(MERS-CoV)流行病、埃博拉流行病和H1N1流行病。在这篇综述中,我们主要关注 CP 疗法的治疗作用及其对抗 COVID-19 爆发的中和作用。