To fully enable the development of diagnostic tools and progressive pharmaceutical drugs, it is imperative to understand the molecular changes occurring before and during disease onset and progression. Systems biology assessments utilizing multi-omic analyses (e.g. the combination of proteomics, lipidomics, genomics, etc.) have shown enormous value in determining molecules prevalent in diseases and their associated mechanisms. Herein, we utilized multi-omic evaluations, multi-dimensional analysis methods, and new cheminformatics-based visualization tools to provide an in depth understanding of the molecular changes taking place in preeclampsia (PRE) and gestational diabetes mellitus (GDM) patients. Since PRE and GDM are two prevalent pregnancy complications that result in adverse health effects for both the mother and fetus during pregnancy and later in life, a better understanding of each is essential. The multi-omic evaluations performed here provide new insight into the end-stage molecular profiles of each disease, thereby supplying information potentially crucial for earlier diagnosis and treatments.

中文翻译：

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利用多组学和创新的化学信息学可视化工具揭示先兆子痫和妊娠糖尿病的分子特征。

为了充分开发诊断工具和先进药物，必须了解疾病发作和进展之前和期间发生的分子变化。利用多组学分析（例如蛋白质组学、脂质组学、基因组学等的组合）的系统生物学评估在确定疾病中普遍存在的分子及其相关机制方面显示出巨大的价值。在此，我们利用多组学评估、多维分析方法和新的基于化学信息学的可视化工具来深入了解先兆子痫（PRE）和妊娠糖尿病（GDM）患者中发生的分子变化。由于 PRE 和 GDM 是两种常见的妊娠并发症，会在怀孕期间和以后的生活中对母亲和胎儿的健康产生不利影响，因此更好地了解每种并发症至关重要。这里进行的多组学评估为每种疾病的终末阶段分子谱提供了新的见解，从而为早期诊断和治疗提供了潜在的关键信息。