The study investigates the prevalence of antimicrobial resistance in Campylobacter jejuni and Campylobacter coli in gastroenteritis patients in the eight most populous regions in Australia and compares the prevalence of antimicrobial resistance in Europe and North America. A total of 164 Campylobacter isolates were collected from patients with campylobacteriosis and tested for susceptibility to six antimicrobials using ETEST^® strips and compared with reports from Europe and the United States. Genomes were sequenced on Illumina NextSeq to identify genetic determinants of resistance. Phenotypically, 1.8%, 14.0%, 14.6%, and 20.1% of isolates were resistant to erythromycin (ERY), ampicillin, tetracycline (TET), and ciprofloxacin (CIP), respectively. Comparing published phenotypic results of antimicrobial resistance in several European countries and the United States with these Australian isolates reveals that rates observed in Australia are among the lowest observed for ERY, CIP, and TET for both C. coli and C. jejuni. For each antimicrobial tested, concordance between resistance phenotype and genotype ranged from 66.6% to 100.0%. This study highlights that, among industrialized countries, Portugal and Spain have very high levels of antimicrobial resistance in C. jejuni and C. coli, especially when compared with the United Kingdom, United States, and Australia.

中文翻译：

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弯曲杆菌属的抗菌素耐药性。在澳大利亚引起人类感染：国际比较

该研究调查了澳大利亚八个人口最多地区胃肠炎患者中空肠弯曲杆菌和大肠杆菌的抗菌素耐药性流行情况，并比较了欧洲和北美的抗菌素耐药性流行情况。从弯曲杆菌病患者中收集了总共 164株弯曲杆菌分离株，并使用 ETEST ^®测试了对六种抗菌药物的敏感性剥离并与来自欧洲和美国的报道进行比较。在 Illumina NextSeq 上对基因组进行测序，以确定耐药性的遗传决定因素。从表型上看，分别有 1.8%、14.0%、14.6% 和 20.1% 的分离株对红霉素 (ERY)、氨苄青霉素、四环素 (TET) 和环丙沙星 (CIP) 具有耐药性。将几个欧洲国家和美国公布的抗菌素耐药性表型结果与这些澳大利亚分离株进行比较表明，在澳大利亚观察到的 ERY、CIP 和 TET 发生率是观察到的最低的大肠杆菌和空肠弯曲杆菌. 对于每种测试的抗菌素，耐药表型和基因型之间的一致性在 66.6% 到 100.0% 之间。该研究强调，在工业化国家中，葡萄牙和西班牙的空肠弯曲杆菌和大肠杆菌的抗菌素耐药性水平非常高，尤其是与英国、美国和澳大利亚相比。