Introduction Although several systematic reviews (SRs)/meta-analyses (MAs) on the association between specific mental disorders and specific somatic conditions are available, an overarching evidence synthesis across mental disorders and somatic conditions is currently lacking. We will conduct an umbrella review of SRs/MAs to test: 1) the strength of the association between individual mental disorders and individual somatic conditions in children/adolescents and adults; 2) to which extent associations are specific to individual mental and somatic conditions . Methods and analysis We will search a broad set of electronic databases and contact study authors. We will include SRs with MA or SRs reporting the effect size from individual studies on the association between a number of somatic and mental conditions (as per the International Classification of Diseases, 11th Revision). We will follow an algorithm to select only one SR or MA when more than one are available on the same association. We will rate the quality of included SRs/MAs using the AMSTAR-2 tool. We will assess to which extent mental disorders are selectively associated with specific somatic conditions or if there are transdiagnostic, across-spectra or diagnostic spectrum-specific associations between mental disorders and somatic conditions based on the Transparent, Reporting, Appraising, Numerating, Showing (TRANSD) recommendations. Discussion The present umbrella review will shed light on the association between mental health disorders and somatic conditions, providing useful data for the care of patients with mental health disorders, in particular for early detection and intervention. This work might also add insight to the pathophysiology of mental health conditions, and contribute to the current debate on the value of a transdiagnostic approach in psychiatry.

中文翻译：

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精神障碍与躯体疾病之间的关联：伞式审查方案。

简介 尽管已有一些关于特定精神障碍和特定躯体疾病之间关联的系统评价（SR）/荟萃分析（MA），但目前缺乏跨精神障碍和躯体疾病的总体证据综合。我们将对 SR/MA 进行总体审查，以测试：1）儿童/青少年和成人个体精神障碍与个体躯体疾病之间关联的强度；2) 关联在多大程度上是针对个人心理和躯体状况的。方法和分析 我们将搜索广泛的电子数据库并联系研究作者。我们将纳入具有 MA 的 SR 或报告一些躯体与精神疾病之间关联的个别研究的效应大小的 SR（根据国际疾病分类第 11 版）。当同一关联上有多个可用的 SR 或 MA 时，我们将遵循一种算法仅选择一个 SR 或 MA。我们将使用 AMSTAR-2 工具对所包含的 SR/MA 的质量进行评级。我们将评估精神障碍在多大程度上与特定的躯体疾病选择性相关，或者基于透明、报告、评估、计算、显示（TRANSD ）建议。讨论 本总体审查将阐明精神健康障碍与躯体疾病之间的关联，为精神健康障碍患者的护理提供有用的数据，特别是早期发现和干预。这项工作还可能增加对心理健康状况病理生理学的见解，并有助于当前关于精神病学跨诊断方法价值的辩论。