Supplemental Digital Content is available in the text. Turner syndrome is caused by complete or partial X monosomy in some or all cells. Cardiovascular complications are dominant, including increased blood pressure (BP), leading to early-onset hypertension. The aim is to describe the debut, development, and treatment of hypertension in Turner syndrome during a 12-year pragmatic interventional study to help identify risk factors associated with hypertension. One hundred and two women (aged 38±11 years, range: 18–62 years) with Turner syndrome verified by karyotyping (45, X: n=58 [57%]) were included consecutively. Ambulatory BPs were recorded over 24 hours with oscillometric measurements every 20 minutes. Antihypertensive treatment was recommended if the BP was above 135/85 mm Hg during the daytime. Overall, systolic BP, diastolic BP, and pulse pressure increased during the study, while heart rate decreased. The number of patients treated with antihypertensive medicine increased from 29 (28.71%) at baseline to 34 (53.13%) at the end of study. Twenty-four–hour systolic BP and 24-hour pulse pressure increased significantly with age, while 24-hour heart rate decreased with age, and diastolic BP was insignificantly affected by age. Antihypertensive treatment lowered systolic BP (24-hour: −5 mm Hg), diastolic BP (24-hour: −5 mm Hg), and diminished the pulse pressure (24-hour: −6 mm Hg) but did not affect nighttime systolic BP. Antihypertensive treatment did not affect heart rate. Our study showed that both systolic and diastolic BP increases significantly in women with Turner syndrome resulting in an increased risk of cardiovascular comorbidities. This increment should be considered of multifactorial origin with many contributing factors which is supported by our results.

中文翻译：

---

在为期 12 年的务实干预研究中，特纳综合征高血压的自然病程

补充数字内容在文本中可用。Turner 综合征是由部分或所有细胞中的完全或部分 X 单体引起的。心血管并发症占主导地位，包括血压升高（BP），导致早发性高血压。目的是在一项为期 12 年的务实干预研究中描述特纳综合征高血压的首次出现、发展和治疗，以帮助确定与高血压相关的危险因素。102 名经核型分析证实的特纳综合征女性（年龄 38±11 岁，范围：18-62 岁）被连续纳入研究（45，X：n=58 [57%]）。动态血压记录超过 24 小时，每 20 分钟进行一次示波测量。如果白天血压高于 135/85 mmHg，建议进行降压治疗。总体而言，收缩压、舒张压、研究期间脉压增加，而心率下降。接受抗高血压药物治疗的患者人数从基线时的 29 人（28.71%）增加到研究结束时的 34 人（53.13%）。24 小时收缩压和 24 小时脉压随年龄增长显着升高，而 24 小时心率随年龄增长而降低，舒张压受年龄影响不显着。抗高血压治疗降低了收缩压（24 小时：-5 毫米汞柱）、舒张压（24 小时：-5 毫米汞柱），并降低了脉压（24 小时：-6 毫米汞柱），但不影响夜间收缩压BP。抗高血压治疗不影响心率。我们的研究表明，特纳综合征女性的收缩压和舒张压均显着增加，导致心血管合并症风险增加。