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Selective enhancement of low-gamma activity by tACS improves phonemic processing and reading accuracy in dyslexia.
PLOS Biology ( IF 9.8 ) Pub Date : 2020-09-08 , DOI: 10.1371/journal.pbio.3000833
Silvia Marchesotti 1 , Johanna Nicolle 1 , Isabelle Merlet 2 , Luc H Arnal 1, 3 , John P Donoghue 4 , Anne-Lise Giraud 1
Affiliation  

The phonological deficit in dyslexia is associated with altered low-gamma oscillatory function in left auditory cortex, but a causal relationship between oscillatory function and phonemic processing has never been established. After confirming a deficit at 30 Hz with electroencephalography (EEG), we applied 20 minutes of transcranial alternating current stimulation (tACS) to transiently restore this activity in adults with dyslexia. The intervention significantly improved phonological processing and reading accuracy as measured immediately after tACS. The effect occurred selectively for a 30-Hz stimulation in the dyslexia group. Importantly, we observed that the focal intervention over the left auditory cortex also decreased 30-Hz activity in the right superior temporal cortex, resulting in reinstating a left dominance for the oscillatory response. These findings establish a causal role of neural oscillations in phonological processing and offer solid neurophysiological grounds for a potential correction of low-gamma anomalies and for alleviating the phonological deficit in dyslexia.



中文翻译:

通过tACS选择性增强低γ活性可改善阅读障碍中的音素处理和阅读准确性。

阅读障碍的语音缺陷与左听皮层的低伽玛振荡功能改变有关,但振荡功能与音素处理之间的因果关系尚未建立。在通过脑电图(EEG)确认30 Hz的缺陷后,我们应用了20分钟的经颅交流电刺激(tACS)来暂时恢复患有阅读障碍的成年人的这种活动。干预措施显着改善了tACS后立即测量的语音处理和阅读准确性。在诵读困难组中,这种效应在30 Hz刺激下选择性发​​生。重要的是,我们观察到对左侧听觉皮层的局灶性干预还降低了右侧颞上皮层的30 Hz活动,从而恢复了振荡反应的左侧优势。

更新日期:2020-09-08
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