SARS-CoV-2 has developed a substantial number of mutations, especially in the S-protein. With the advancement of the pandemic, accumulations of further mutations at the S-protein receptor-binding domain could enhance the infectivity and pathogenicity of the virus. Prediction and evaluation of such mutations are essential for understanding the potential development of more pathogenic strains and for COVID-19 management.

中文翻译：

---

SARS-CoV-2 能否在 S 蛋白中积累突变以增加致病性？

SARS-CoV-2 已经发生了大量突变，尤其是在 S 蛋白中。随着大流行的进展，S蛋白受体结合域进一步突变的积累可以增强病毒的传染性和致病性。对此类突变的预测和评估对于了解更多致病菌株的潜在发展和 COVID-19 管理至关重要。