PPh3/I2-catalyzed one-pot synthesis of 4,6-diarylpyrimidin-2(1H)-ones,Synthetic Communications

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PPh3/I2-catalyzed one-pot synthesis of 4,6-diarylpyrimidin-2(1H)-ones
Synthetic Communications ( IF 2.1 ) Pub Date : 2020-09-08 , DOI: 10.1080/00397911.2020.1815784
Yanzhi Zhang ₁ , Min Lei _{2,

3} , Kangsheng Xue ₄ , Guoxiang Sun _{4,

5} , Yang Zhou _{2,

3} , Jinjun Hou _{2,

3} , Huali Long _{2,

3} , Zijia Zhang _{2,

3} , Xubing Chen ₁ , Wanying Wu _{2,

3}

Affiliation

Abstract A method using PPh3/I2-catalyzed three-component Biginelli reaction of aromatic ketone, aromatic aldehyde and urea to synthesize4,6-diarylpyrimidin-2-(1H)-ones is described. Under the experimental conditions, the main reaction products are 4,6-diarylpyrimidin-2-(1H)-ones not 4,6-diaryl-3,4-dihydropyrimidin-2(1H)-ones. The advantage of this method is to achieve improved product yields with an inexpensive and readily available catalyst, and easy experimental set-up, which provides a good method to synthesize 4,6-diarylpyrimidin-2-(1H)-ones. Graphical Abstract

中文翻译：

PPh3/I2 催化一锅法合成 4,6-diarylpyrimidin-2(1H)-ones

摘要介绍了一种利用PPh3/I2催化芳香酮、芳香醛和尿素三组分Biginelli反应合成4,6-二芳基嘧啶-2-(1H)-酮的方法。在实验条件下，主要反应产物是 4,6-二芳基嘧啶-2-(1H)-ones 而不是 4,6-diaryl-3,4-dihydropyrimidin-2(1H)-ones。这种方法的优点是使用廉价易得的催化剂和简单的实验装置实现了更高的产品收率，这为合成 4,6-二芳基嘧啶-2-(1H)-酮提供了一种很好的方法。图形概要

更新日期：2020-09-08

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