Abstract Infections caused by Campylobacter spp. continue to be a serious health burden worldwide. The importance of Campylobacter jejuni/coli for the development of acute gastroenteritis in Bulgaria has not been studied well yet, especially in early childhood. In this study, we report the incidence and the course of infection with C. jejuni/coli in early childhood and the antibiotic resistance of the clinical isolates tested. Bacteriological examination, followed by Multiplex polymerase chain reaction (PCR), was used. A total of 139 isolates of Campylobacter spp. were obtained from 368 fecal samples from children aged 0–5 years. The C. jejuni strains were 122 (87.8%), and C. coli strains 17 (12.2%). Antibiotic resistance was determined using disc diffusion tests. Resistance to tetracycline (38.1%) and ciprofloxacin (22.1%) was observed, as well as co-resistance to both antibiotics (15.1%). There is a relatively high incidence of campylobacteriosis in hospitalized children with diarrhea. The increasing resistance to quinolone and non-quinolone antibiotics is of concern.

中文翻译：

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保加利亚儿童弯曲杆菌感染：分子特征和抗菌药物敏感性

摘要 弯曲杆菌属引起的感染。继续成为世界范围内严重的健康负担。空肠弯曲杆菌/大肠杆菌对保加利亚急性胃肠炎发展的重要性尚未得到很好的研究，尤其是在儿童早期。在这项研究中，我们报告了儿童早期空肠弯曲杆菌/大肠杆菌感染的发生率和病程，以及所测试的临床分离株的抗生素耐药性。使用细菌学检查，然后进行多重聚合酶链反应 (PCR)。共有 139 株弯曲杆菌属。来自 0-5 岁儿童的 368 个粪便样本。空肠弯曲杆菌菌株为 122 (87.8%)，大肠杆菌菌株为 17 (12.2%)。使用圆盘扩散试验确定抗生素抗性。观察到对四环素 (38.1%) 和环丙沙星 (22.1%) 的耐药性，以及对两种抗生素的共同耐药性 (15.1%)。住院腹泻儿童弯曲杆菌病的发生率相对较高。对喹诺酮类和非喹诺酮类抗生素日益增加的耐药性令人担忧。