ABSTRACT

The circadian rhythm, with the form of a transcription-translation negative feedback loop, is present in skeletal muscle tissue and is regulated by several core clock genes. In addition, circadian transcriptomic studies have revealed that there are hundreds of genes with rhythmic expression patterns in skeletal muscle, and these expression patterns are important for the maintenance of the physiological functions of skeletal muscle. Accumulating evidence suggests that abnormal skeletal muscle circadian rhythms disrupt the metabolism of glucose, lipids, and amino acids, and increase the risk of metabolic diseases such as obesity and diabetes. This review aims to provide a more detailed overview of the skeletal muscle clock and its relationship with metabolism based on the current state of knowledge. We first reviewed the research being done on the skeletal muscle clock and the regulation mechanism of the circadian rhythm. With the in-depth study of skeletal muscle clock control genes (CCGs), it has been found that many genes are involved in the regulation of skeletal muscle energy metabolism. On this basis, we further discussed the evidence on how circadian genes in skeletal muscle regulate glucose, lipid, and protein metabolism. This will help provide valuable insights into the relationship between metabolic diseases and the skeletal muscle clock.

摘要

昼夜节律以转录-翻译负反馈环的形式存在于骨骼肌组织中，并受几个核心时钟基因的调节。此外，昼夜节律转录组学研究表明，骨骼肌中有数百个基因具有节律性表达模式，这些表达模式对于维持骨骼肌的生理功能很重要。越来越多的证据表明，骨骼肌昼夜节律异常会破坏葡萄糖、脂质和氨基酸的代谢，并增加肥胖和糖尿病等代谢疾病的风险。本综述旨在根据当前的知识状态，更详细地概述骨骼肌时钟及其与新陈代谢的关系。我们首先回顾了正在进行的关于骨骼肌时钟和昼夜节律调节机制的研究。随着对骨骼肌时钟控制基因（CCGs）的深入研究，发现许多基因参与了骨骼肌能量代谢的调控。在此基础上，我们进一步讨论了骨骼肌中昼夜节律基因如何调节葡萄糖、脂质和蛋白质代谢的证据。这将有助于为代谢疾病和骨骼肌时钟之间的关系提供有价值的见解。我们进一步讨论了骨骼肌中昼夜节律基因如何调节葡萄糖、脂质和蛋白质代谢的证据。这将有助于为代谢疾病和骨骼肌时钟之间的关系提供有价值的见解。我们进一步讨论了骨骼肌中昼夜节律基因如何调节葡萄糖、脂质和蛋白质代谢的证据。这将有助于为代谢疾病和骨骼肌时钟之间的关系提供有价值的见解。