Abstract

Mortality level is worsening the situation worldwide thru blood diseases and greatly jeopardizes the human health with poor diagnostics. Due to the lack of successful generation of early diagnosis, the survival rate is currently lower. To overcome the present hurdle, new diagnostic methods have been choreographed for blood disease biomarkers analyses with the conjunction of ultra-small ideal gold nanohybrids. Gold-hybrids hold varieties of unique features, such as high biocompatibility, increased surface-to-volume ratio, less-toxicity, ease in electron transfer and have a greater localized surface plasmon resonance. Gold-nanocomposites can be physically hybrid on the sensor surface and functionalize with the biomolecules using appropriate chemical conjugations. Revolutionizing biosensor platform can be prominently linked for the nanocomposite applications in the current research on medical diagnosis. This review encloses the new developments in diagnosing blood biomarkers by utilizing the gold-nanohybrids. Further, the current state-of-the-art and the future envision with digital monitoring for facile telediagnosis were narrated.

摘要

通过血液疾病，死亡率水平正在恶化世界范围内的情况，并且由于诊断不佳而极大地危害了人类健康。由于缺乏早期诊断的成功生成，目前存活率较低。为了克服目前的障碍，已经为血液疾病生物标志物分析设计了新的诊断方法，并结合了超小的理想金纳米杂化物。金杂化物具有多种独特的特性，例如高生物相容性、增加的表面体积比、毒性较小、易于电子转移以及具有更大的局部表面等离子体共振。金纳米复合材料可以在传感器表面物理混合，并使用适当的化学缀合与生物分子功能化。革命性的生物传感器平台可以与当前医学诊断研究中的纳米复合材料应用密切相关。这篇综述介绍了利用金纳米杂交体诊断血液生物标志物的新进展。此外，还叙述了当前最先进的技术和未来对便捷远程诊断的数字监控的设想。