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Applications of microbial co‐cultures in polyketides production
Journal of Applied Microbiology ( IF 4 ) Pub Date : 2020-09-08 , DOI: 10.1111/jam.14845
X Xu 1 , R Qu 1 , W Wu 1 , C Jiang 1 , D Shao 1 , J Shi 1
Affiliation  

Polyketides are a large group of natural biomolecules that are normally produced by bacteria, fungi and plants. These molecules have clinical importance due to their anti‐cancer, anti‐microbial, anti‐oxidant and anti‐inflammatory properties. Polyketides are biosynthesized from units of acyl‐CoA by different polyketide synthases (PKSs), which display wide diversity of functional domains and mechanisms of action between fungi and bacteria. Co‐culture of different micro‐organisms can produce novel products distinctive from those produced during single cultures. This study compared the new polyketides produced in such co‐culture systems and discusses aspects of the cultivation systems, product structures and identification techniques. Current results indicate that the formation of new polyketides may be the result of activation of previously silent PKSs genes induced during co‐culture. This review indicated a potential way to produce pure therapeutic polyketides by microbial fermentation and a potential way to develop functional foods and agricultural products using co‐co‐culture of different micro‐organisms. It also pointed out a new perspective for studies on the process of functional foods, especially those involving multiple micro‐organisms.

中文翻译:

微生物共培养在聚酮化合物生产中的应用

聚酮化合物是一大类通常由细菌,真菌和植物产生的天然生物分子。这些分子具有抗癌,抗微生物,抗氧化和抗炎的特性,因此具有临床重要性。聚酮化合物是由酰基-CoA单元通过不同的聚酮化合物合酶(PKS)生物合成的,后者显示出功能域的广泛多样性以及真菌和细菌之间的作用机理。不同微生物的共培养可以产生不同于单一培养的新颖产品。这项研究比较了在这种共培养系统中产生的新型聚酮化合物,并讨论了培养系统,产品结构和鉴定技术的各个方面。目前的结果表明,新的聚酮化合物的形成可能是共培养过程中先前沉默的PKSs基因激活的结果。这篇综述指出了通过微生物发酵生产纯治疗性聚酮化合物的潜在方法,以及通过使用不同微生物的共培养来开发功能性食品和农产品的潜在方法。它还为功能性食品,尤其是涉及多种微生物的功能食品的加工研究提供了新的视角。
更新日期:2020-09-08
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