Limbic‐predominant age‐related TDP‐43 encephalopathy neuropathological change (LATE‐NC) is present in approximately 50% of Alzheimer's disease (AD) cases and is associated with accelerated cognitive decline. Studies indicate a potential synergistic relationship between LATE‐NC and hyperphosphorylated tau. It is unknown if LATE‐NC is an independent driver of cognitive impairment or exerts its influence through synergistic relationships with tau. This cliniconeuropathological study investigated the impact of LATE‐NC on quantified measures of AD‐associated pathology and its impact on clinical measures.

中文翻译：

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阿尔茨海默病中伴随的 LATE-NC 与增加的 tau 或淀粉样蛋白 β 病理负担无关

大约 50% 的阿尔茨海默病 (AD) 病例存在边缘边缘主导的与年龄相关的 TDP-43 脑病神经病理学变化 (LATE-NC)，并与认知能力加速下降有关。研究表明 LATE-NC 和过度磷酸化的 tau 之间存在潜在的协同关系。目前尚不清楚 LATE-NC 是认知障碍的独立驱动因素还是通过与 tau 的协同关系发挥其影响。这项临床神经病理学研究调查了 LATE-NC 对 AD 相关病理量化测量的影响及其对临床测量的影响。