The Harzialactone A synthesis utilizes a Horner–Wittig‐reaction of the chiral building block and benzaldehyde in the first step. The formed β‐hydroxy ketone can be selectively transformed into the syn‐ or anti‐diol, which is further converted into the desired natural compound by ozonolysis, cyclization and oxidation in one step.

中文翻译：

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使用标准的聚酮化合物构建基体立体控制合成Harzialactone A及其三种立体异构体

第一步，Harzialactone A合成利用手性结构单元和苯甲醛的Horner-Wittig反应。形成的β-羟基酮可以选择性地转化为顺式或反式二醇，然后通过臭氧分解，环化和氧化一步转化为所需的天然化合物。