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Differential influences of the BPA, BPS and BPF on in vitro IL-17 secretion by mouse and human T cells.
Toxicology in Vitro ( IF 3.2 ) Pub Date : 2020-09-08 , DOI: 10.1016/j.tiv.2020.104993
Yann Malaisé 1 , Hélène Le Mentec 2 , Lydie Sparfel 2 , Laurence Guzylack-Piriou 1
Affiliation  

The endocrine disruptor and food contaminant bisphenol A (BPA) is frequently present in consumer plastics and can produce several adverse health effects participating in the development of inflammatory and autoimmune diseases. Regulatory restrictions have been established to prevent risks for human health, leading to the substitution of BPA by structural analogues, such as bisphenol S (BPS) and F (BPF). In this study, we aimed at comparing the in vitro impact of these bisphenols from 0.05 to 50,000 nM on Th17 differentiation, frequency and function in mouse systemic and intestinal immune T cells and in human blood T cells. This study reports the ability of these bisphenols, at low and environmentally relevant concentration, i.e, 0.05 nM, to increase significantly IL-17 production in mouse T cells but not in human T lymphocytes. The use of an aryl hydrocarbon receptor (AhR) specific inhibitor demonstrated its involvement in this bisphenol-induced IL-17 production. We also observed an increased IL-17 secretion by BPS and BPF, and not by BPA, in mouse naive T cells undergoing in vitro Th17 differentiation. In total, this study emphasizes the link between bisphenol exposures and the susceptibility to develop immune diseases, questioning thus the rational of their use to replace BPA.



中文翻译:

BPA、BPS 和 BPF 对小鼠和人 T 细胞体外 IL-17 分泌的不同影响。

内分泌干​​扰物和食品污染物双酚 A (BPA) 经常存在于消费塑料中,可产生多种不良健康影响,参与炎症和自身免疫性疾病的发展。已制定监管限制以防止对人类健康造成风险,导致双酚 S (BPS) 和 F (BPF) 等结构类似物替代 BPA。在本研究中,我们旨在比较这些 0.05 至 50,000 nM 的双酚对小鼠全身和肠道免疫 T 细胞以及人血 T 细胞中 Th17 分化、频率和功能的体外影响。本研究报告了这些双酚在低且与环境相关的浓度下的能力,, 0.05 nM,显着增加小鼠 T 细胞中 IL-17 的产生,但不增加人 T 淋巴细胞中的产生。芳烃受体 (AhR) 特异性抑制剂的使用证明其参与了这种双酚诱导的 IL-17 产生。我们还观察到,在经历体外Th17 分化的小鼠幼稚 T 细胞,BPS 和 BPF 而不是 BPA 增加了 IL-17 分泌。总的来说,这项研究强调了双酚暴露与发展免疫疾病的易感性之间的联系,从而质疑使用双酚替代 BPA 的合理性。

更新日期:2020-09-14
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