Abstract Ipriflavone is a drug widely used in clinical treatment and prevention of osteoporosis, and it also has a certain protective effect on the nervous system. In this work, the laser dynamic method was used to measure the solubility data of IP in three binary solvents under normal pressure (temperature range: 278.15 K to 323.15 K). The results show that as both the mass fraction of positive solvents (NMP, DMF, DMAC) in the binary mixed solvents and the temperature increase, the solubility of IP increases. In addition, the Hansen solubility parameter (HSP) was used to analyze the order of solubility. The results indicated that the selected solubility parameters (Δδd, Δδp, Δδh, Δδt and Δδ) could explain the solubility trend well. Furthermore, the modified Apelblat equation, λH equation, NRTL model and UNIQUAC model were used to correlate the solubility data in binary mixed solvents. By calculating the deviation between the experimental data and the fitting data, it shows that the selected models have a good correlation with the solubility data of IP. Finally, the modified van’t Hoff equation was used to calculate the apparent thermodynamic properties of IP during the dissolution process. The results show that the dissolution process is always endothermic and entropy driven.

中文翻译：

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异黄酮在三种二元溶剂中的溶解度测量、模型评价及汉森溶解度参数

摘要 艾普黄酮是临床上广泛用于治疗和预防骨质疏松症的药物，对神经系统也有一定的保护作用。在这项工作中，激光动力学方法用于测量常压下（温度范围：278.15 K 至 323.15 K）IP 在三种二元溶剂中的溶解度数据。结果表明，随着二元混合溶剂中正溶剂（NMP、DMF、DMAC）的质量分数和温度的升高，IP的溶解度增加。此外，使用汉森溶解度参数（HSP）来分析溶解度的顺序。结果表明，选定的溶解度参数（Δδd、Δδp、Δδh、Δδt和Δδ）可以很好地解释溶解度趋势。此外，修正的 Apelblat 方程，λH 方程，NRTL 模型和UNIQUAC 模型用于关联二元混合溶剂中的溶解度数据。通过计算实验数据与拟合数据的偏差，表明所选模型与IP的溶解度数据具有良好的相关性。最后，使用修正的范特霍夫方程计算溶解过程中 IP 的表观热力学性质。结果表明，溶解过程始终是吸热和熵驱动的。