Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus.,Neuron

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Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus.
Neuron ( IF 16.2 ) Pub Date : 2020-09-08 , DOI: 10.1016/j.neuron.2020.08.013
Hankyul Kwak ₁ , Wuhyun Koh ₂ , Sangwoo Kim ₁ , Kiyeong Song ₁ , Jeong-Im Shin ₃ , Jung Moo Lee ₄ , Elliot H Lee ₁ , Jin Young Bae ₅ , Go Eun Ha ₁ , Ju-Eun Oh ₆ , Yongmin Mason Park ₂ , Sunpil Kim ₇ , Jiesi Feng ₈ , Seung Eun Lee ₉ , Ji Won Choi ₁₀ , Ki Hun Kim ₁₁ , Yoo Sung Kim ₁₂ , Junsung Woo ₁₃ , Dongsu Lee ₁ , Taehwang Son ₁₄ , Soon Woo Kwon ₁₅ , Ki Duk Park ₁₆ , Bo-Eun Yoon ₁₂ , Jaeick Lee ₁₁ , Yulong Li ₁₇ , Hyunbeom Lee ₆ , Yong Chul Bae ₅ , C Justin Lee ₂ , Eunji Cheong ₁₈

Affiliation

Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea.
Division of Bio-Medical Science &Technology, KIST School, Korea University of Science and Technology, Seoul 02792, South Korea; Center for Glia-Neuron Interaction, Korea Institute of Science and Technology, Seoul 02792, South Korea; Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, South Korea.
Division of Bio-Medical Science &Technology, KIST School, Korea University of Science and Technology, Seoul 02792, South Korea; Center for Glia-Neuron Interaction, Korea Institute of Science and Technology, Seoul 02792, South Korea.
Center for Glia-Neuron Interaction, Korea Institute of Science and Technology, Seoul 02792, South Korea; Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, South Korea; KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, South Korea.
Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu 41566, South Korea.
Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul 02792, South Korea.
Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, South Korea; KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, South Korea.
State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
Virus Facility, Research Animal Resource Center, Korea Institute of Science and Technology, Seoul 02792, South Korea.
Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul 02792, South Korea.
Doping Control Center, Korea Institute of Science and Technology, Seoul 02792, South Korea.
Department of Molecular Biology, College of Natural Science, Dankook University, Cheonan 31116, South Korea.
Center for Glia-Neuron Interaction, Korea Institute of Science and Technology, Seoul 02792, South Korea.
School of Electrical and Electronic Engineering, Yonsei University, Seoul 03722, South Korea.
Radiation Medicine Clinical Research Division, Korea Institute of Radiological and Medical Sciences, Seoul, South Korea.
Division of Bio-Medical Science &Technology, KIST School, Korea University of Science and Technology, Seoul 02792, South Korea; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul 02792, South Korea; KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul 02447, South Korea.
State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 100871, China.
Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea; POSTECH Biotech Center, POSTECH, Pohang, South Korea.

Sensory discrimination is essential for survival. However, how sensory information is finely controlled in the brain is not well defined. Here, we show that astrocytes control tactile acuity via tonic inhibition in the thalamus. Mechanistically, diamine oxidase (DAO) and the subsequent aldehyde dehydrogenase 1a1 (Aldh1a1) convert putrescine into GABA, which is released via Best1. The GABA from astrocytes inhibits synaptically evoked firing at the lemniscal synapses to fine-tune the dynamic range of the stimulation-response relationship, the precision of spike timing, and tactile discrimination. Our findings reveal a novel role of astrocytes in the control of sensory acuity through tonic GABA release.

中文翻译：

星形胶质细胞通过丘脑中的补药抑制来控制感觉敏锐度。

感觉辨别对于生存至关重要。但是，如何很好地控制大脑中的感官信息尚不清楚。在这里，我们显示星形胶质细胞通过丘脑中的补品抑制来控制触觉敏锐度。从机理上讲，二胺氧化酶（DAO）和随后的醛脱氢酶1a1（Aldh1a1）将腐胺转化为GABA，并通过Best1释放。星形胶质细胞中的GABA抑制突触突触突触诱发的放电，以微调刺激-应答关系的动态范围，尖峰时间的精确度和触觉辨别力。我们的发现揭示了星形胶质细胞在通过滋补GABA释放控制感觉敏锐度方面的新作用。

更新日期：2020-09-08

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