Copper is well known for its multifunctional biological effects including antibacterial and angiogenic activities, while silicon-containing bioceramic has proved to possess superior biological properties to hydroxyapatite (HA). In this work, CuO was introduced to silicocarnotite (Ca₅(PO₄)₂SiO₄, CPS) to simultaneously enhance its mechanical and antibacterial properties, and its cytocompatibility was also evaluated. Results showed that CuO could significantly facilitate the densification process of CPS bioceramic through liquid-phase sintering. The bending strength of CPS with the addition of 3.0 wt.% CuO improved from 29.2 MPa to 63.4 MPa after sintered at 1200 °C. Moreover, Cu-CPS bioceramics demonstrated superior in vitro antibacterial property against both S. aureus and E. coli strains by destroying their membrane integrity, and the antibacterial activity augmented with CuO content. Meanwhile, the released Cu ions from Cu-CPS bioceramics could promote the proliferation of human umbilical vein endothelial cells (HUVECs), and the in vitro cytocompatibility exhibited concentration dependence on Cu ions. These suggest that Cu-CPS bioceramics might be promising candidates for bone tissue regeneration with an ability to prevent postoperative infections.

铜以其多功能的生物作用（包括抗菌和血管生成活性）而闻名，而含硅的生物陶瓷已被证明具有比羟基磷灰石（HA）优越的生物学特性。在这项工作中，将CuO引入硅钙锰矿（Ca ₅（PO ₄）₂ SiO ₄，CPS）中，以同时增强其机械和抗菌性能，并评估了其细胞相容性。结果表明，CuO可以通过液相烧结显着促进CPS生物陶瓷的致密化过程。CPS的弯曲强度加上3.0 wt。在1200°C烧结后，％CuO从29.2 MPa提高到63.4 MPa。此外，Cu-CPS生物陶瓷通过破坏金黄色葡萄球菌和大肠埃希菌的膜完整性，对金黄色葡萄球菌和大肠杆菌均表现出优异的体外抗菌性能，并且其抗菌活性随CuO含量的增加而增加。同时，Cu-CPS生物陶瓷中释放的Cu离子可促进人脐静脉内皮细胞（HUVECs）的增殖，并且体外细胞相容性表现出对Cu离子的浓度依赖性。这些表明，Cu-CPS生物陶瓷具有预防术后感染的能力，有望成为骨组织再生的有希望的候选者。