BACKGROUND The pathophysiological mechanisms underlying the associations of multiple sclerosis (MS) neurodegeneration serum cholesterol profiles is currently unknown. OBJECTIVE To determine associations between lipid profile measures and cerebral perfusion-based indices in MS patients. METHODS Seventy-seven MS patients underwent 3 T MRI. Cerebral blood volume (CBV), time-to-peak (TTP) and mean transit time (MTT) measures were computed from dynamic susceptibility contrast (DSC) perfusion-weighted imaging (PWI) for normal-appearing brain tissue (NABT), GM, cortex, deep gray matter (DGM) and thalamus. Total cholesterol, low and high-density lipoprotein cholesterol (LDL-C and HDL-C) and the apolipoproteins (Apo), ApoA-I, ApoA-II, ApoB, ApoC-II and ApoE levels were measured in plasma. Age and body mass index (BMI)-adjusted correlations were used to assess the associations between PWI and lipid profile measures. RESULTS Higher HDL-C levels were associated with shorter MTT, which are indicative of greater perfusion, in NABT (p = 0.012), NAWM (p = 0.021), GM (p = 0.009), cortex (p = 0.014), DGM p = 0.015; and thalamus p = 0.015). The HDL-C-associated apolipoproteins, ApoA-I and ApoA-II, were associated with shorter MTT of the same brain regions (all p < 0.028). HDL-C and ApoA-I levels were also associated with shorter TTP, indicative of faster cerebral blood delivery. ApoC-II was associated with lower nCBV of the GM and cortex (p = 0.035 and p = 0.014, respectively). CONCLUSION The HDL pathway is associated with better global brain perfusion and faster cerebral blood delivery as measured by shorter MTT and TTP, respectively. ApoC-II may be associated with lower cortical and DGM perfusion.

中文翻译：

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高密度脂蛋白胆固醇和载脂蛋白 AI 与多发性硬化症的脑灌注增加有关

背景 多发性硬化症 (MS) 神经变性血清胆固醇谱相关性的病理生理机制目前尚不清楚。目的 确定 MS 患者血脂谱测量与基于脑灌注的指数之间的关联。方法 77 名 MS 患者接受了 3 T MRI。脑血容量 (CBV)、达峰时间 (TTP) 和平均传输时间 (MTT) 测量值由动态磁敏感对比 (DSC) 灌注加权成像 (PWI) 计算，用于正常外观的脑组织 (NABT)、GM 、皮层、深部灰质 (DGM) 和丘脑。测量血浆中的总胆固醇、低密度和高密度脂蛋白胆固醇（LDL-C 和 HDL-C）以及载脂蛋白（Apo）、ApoA-I、ApoA-II、ApoB、ApoC-II 和 ApoE 水平。年龄和体重指数 (BMI) 调整后的相关性用于评估 PWI 和脂质分布测量值之间的关联。结果 在 NABT (p = 0.012)、NAWM (p = 0.021)、GM (p = 0.009)、皮质 (p = 0.014)、DGM p 中，较高的 HDL-C 水平与较短的 MTT 相关，这表明灌注较大= 0.015; 和丘脑 p = 0.015）。HDL-C 相关的载脂蛋白 ApoA-I 和 ApoA-II 与相同大脑区域的较短 MTT 相关（所有 p < 0.028）。HDL-C 和 ApoA-I 水平也与较短的 TTP 相关，表明更快的脑血输送。ApoC-II 与 GM 和皮质的较低 nCBV 相关（分别为 p = 0.035 和 p = 0.014）。结论 HDL 通路与更好的整体脑灌注和更快的脑血输送相关，分别通过更短的 MTT 和 TTP 测量。