Galectin-3 (Gal3) is expressed by microglia and performs functions including adhesion; activation of macrophages and fibroblasts, and mediates inflammatory responses in the hippocampus. The present study examined whether serum Gal3 levels predict hippocampal volume in a multi-ethnic, community-based sample. Results of a multiple linear regression (controlling for depression, serum creatinine level, age, BMI, total brain volume, MoCA score, sex, ethnicity, smoking status, history of diabetes) showed that Gal3 levels significantly predicted left (p = .027) but not right hippocampal volume. The relationship was stronger in men than women. Findings suggest this novel inflammatory biomarker is associated with human hippocampal volume.

中文翻译：

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社区研究中炎症生物标志物 galectin-3 与海马体积的关系

Galectin-3 (Gal3) 由小胶质细胞表达并执行包括粘附在内的功能；巨噬细胞和成纤维细胞的活化，并介导海马中的炎症反应。本研究检查了血清 Gal3 水平是否可以预测多民族、基于社区的样本中的海马体积。多元线性回归的结果（控制抑郁症、血清肌酐水平、年龄、BMI、总脑容量、MoCA 评分、性别、种族、吸烟状况、糖尿病史）显示 Gal3 水平显着预测左侧 (p = .027)但不是正确的海马体积。这种关系在男性中比女性更强。研究结果表明，这种新型炎症生物标志物与人类海马体积有关。