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Individual differences in accumbofrontal tract integrity relate to risky decisions under stress in adolescents and adults.
Developmental Cognitive Neuroscience ( IF 4.7 ) Pub Date : 2020-09-08 , DOI: 10.1016/j.dcn.2020.100859
Jessica P Uy 1 , Adriana Galván 1
Affiliation  

Psychosocial stress increases risky decision-making (DM). It is widely accepted that individual variation in neural phenotypes underlie variability in this behavioral tendency in adults, but is less examined in adolescents. Our goal was to test the hypothesis that the relation between neural phenotypes and stress-related risky DM is better characterized by individual variation than by age. Using diffusion tensor imaging (DTI) tractography to characterize the accumbofrontal tract, we determined if it uniquely moderated how stress affects risky DM, over and above age. A daily diary design monitored participants’ daily stress for two weeks. Participants completed a DTI scan and performed a task in which decisions varied by expected value, once each on a day when they endorsed feeling higher (and lower) than usual levels of stress. Multilevel logistic regression analyses revealed that all participants were more likely to take risks as expected reward value increased; this behavior was greater under high versus low stress for individuals with low accumbofrontal tract integrity, whereas DM was less influenced by stress for individuals with high accumbofrontal tract integrity, regardless of age. Results suggest that individual differences in brain structure may be more germane to characterizing risky decisions in adolescents, rather than ontogeny.



中文翻译:

在青少年和成年人的压力下,前额叶完整性的个体差异与危险的决定有关。

社会心理压力会增加风险决策(DM)。人们普遍接受的是,神经表型的个体差异是成年人这种行为趋势的可变因素,但在青少年中较少进行检查。我们的目标是检验以下假设,即与个体年龄相比,个体差异更好地表征了神经表型和与压力相关的危险性DM之间的关系。我们使用弥散张量成像(DTI)超声成像来表征额额肌束,我们确定了它是否能唯一缓解压力如何影响年龄以上的危险DM。每日日记设计监控参与者的两周日常压力。参与者完成了一次DTI扫描,并执行了一项决策,该决策根据期望值而变化,每天一次,他们认可的感觉要比平常的压力水平更高(和更低)。多级逻辑回归分析表明,随着预期奖励价值的增加,所有参与者更有可能冒险。对于具有高额顶额束完整性的个体,在高压力下与低压力下相比,这种行为更为明显,而对于高额顶额束完整性的个体,无论年龄大小,DM受压力的影响较小。结果表明,大脑结构的个体差异可能与表征青少年的危险决定而不是个体发育更密切相关。不论年纪。结果表明,大脑结构的个体差异可能与表征青少年的危险决定而不是个体发育更密切相关。不论年纪。结果表明,大脑结构的个体差异可能与表征青少年的危险决定而不是个体发育更密切相关。

更新日期:2020-09-08
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