Several studies have investigated a potential association between the endothelial lipase gene (LIPG) 584C/T polymorphism and susceptibility to coronary artery disease (CAD), but a uniform conclusion has yet to be reached. To better evaluate the true relationship between the LIPG 584C/T polymorphism and the risk of CAD, a meta-analysis of fourteen case-control studies with 9,731 subjects was performed. Relevant articles published through August 2020 were searched in the CNKI, PubMed, Embase and Web of Science databases. Thirteen articles, including fourteen eligible case-control studies with 4,025 cases and 5,706 controls, were enrolled in the present meta-analysis. The NOS scores of the case-control studies ranged from 6 to 8. The pooled results indicated that there is a significant association between the LIPG 584C/T polymorphism and CAD in the homozygote comparison model and the allelic comparison model. Subgroup analyses revealed that the LIPG 584C/T mutation significantly decreased the risk of CAD in the subgroups of African, CAD, hospital-based (HB), and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) populations in some genetic models. No publication bias was founded in our meta-analysis, which certifies the robustness of the current meta-analysis. TSA also confirmed the stability of our results. The results of our meta-analysis indicate that the LIPG 584C/T polymorphism plays a protective role in the incidence of coronary artery disease. More high-quality case-control studies on various ethnicities are needed to confirm our results.

中文翻译：

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内皮脂肪酶基因584C / T多态性与冠心病风险之间存在显着关联。

几项研究调查了内皮脂肪酶基因（LIPG）584C / T多态性与冠状动脉疾病（CAD）的易感性之间的潜在关联，但尚未得出统一的结论。为了更好地评估LIPG 584C / T多态性与CAD风险之间的真实关系，对14例病例对照研究进行了荟萃分析，涉及9,731名受试者。在CNKI，PubMed，Embase和Web of Science数据库中搜索了到2020年8月发布的相关文章。本荟萃分析纳入了十三篇文章，包括十四项符合条件的病例对照研究，其中包括4,025例病例和5,706例对照。病例对照研究的NOS得分为6到8。汇总结果表明，在纯合子比较模型和等位基因比较模型中，LIPG 584C / T多态性与CAD之间存在显着关联。亚组分析表明，在某些遗传模型中，LIPG 584C / T突变显着降低了非洲人，CAD，医院（HB）和聚合酶链反应限制片段长度多态性（PCR-RFLP）人群中亚组的CAD风险。 。我们的荟萃分析未发现任何发表偏见，这证明了当前荟萃分析的稳健性。TSA还证实了我们结果的稳定性。我们的荟萃分析结果表明，LIPG 584C / T多态性在冠心病的发病中起保护作用。需要对不同种族进行更多高质量的病例对照研究，以证实我们的结果。