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Pd/NBE-catalyzed sequential carbamoylation/olefination of aryl iodides
Organic Chemistry Frontiers ( IF 5.4 ) Pub Date : 2020-09-07 , DOI: 10.1039/d0qo00905a
Chen Chen 1, 2, 3, 4, 5 , Liying Liu 1, 2, 3, 4, 5 , Wan Sun 1, 2, 3, 4, 5 , Jie Ding 1, 2, 3, 4, 5 , Yan-Ping Zhu 6, 7, 8, 9, 10 , Bolin Zhu 1, 2, 3, 4, 5
Affiliation  

We report a palladium/norbornene cooperative catalyzed ortho-carbamoylation/ipso-Heck cyclization of aryl iodides using alkene-tethered carbamoyl chlorides. This reaction was carried out using readily available starting materials under mild reaction conditions, and a variety of 4-methylene-3,4-dihydro-1(2H)-isoquinolin-1-one analogues were obtained in moderate to good yields.

中文翻译:

Pd / NBE催化的芳基碘化物的连续氨基甲酸酯化/烯化

我们报告钯/降冰片烯合作催化-carbamoylation / IPSO使用烯烃-拴系的氨基甲酰氯芳基碘的-Heck环。使用容易获得的起始原料在温和的反应条件下进行该反应,并以中等至良好的产率获得了各种4-亚甲基-3,4-二氢-1(2H)-异喹啉-1-酮类似物。
更新日期:2020-10-13
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