Traditional Chinese medicines and their products contain complex active compounds whose quality control is challenging and hence has drawn extensive attention. The Zhenju Jiangya tablet (ZHJYP) is a compound preparation of Chinese and Western medicine mainly used in the treatment of mild to moderate hypertension. In this paper, the pretreatment method of multi-peak fitting was applied to establish an infrared quantitative model in order to predict the content of the main components in ZHJYP. Secondly, the QAMS method was applied to ZHJYP with one of its chemical components (HCT) used as an internal standard to determine the content of the other two active components. Finally, the infrared fingerprint and HPLC fingerprint were established to comprehensively evaluate the quality consistency of ZHJYP. The results showed that the established infrared quantitative model achieved better performance in predicting the content of active components. In addition, there was no significant difference between the contents of the two components calculated by the QAMS method and the external standard method (ESM). In summary, the two methods of assay of active components combined with the fingerprint analysis will provide a valuable reference for the analysis of active compounds and the overall quality control of ZHJYP.

中文翻译：

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珍菊降压片质量控制的红外定量模型建立，单组分多组分定量分析和集成指纹法

中药及其产品含有复杂的活性化合物，其质量控制具有挑战性，因此引起了广泛关注。珍菊降压片（ZHJYP）是中西医结合制剂，主要用于治疗轻中度高血压。本文采用多峰拟合的预处理方法建立红外定量模型，以预测ZHJYP中主要成分的含量。其次，将QAMS方法应用于ZHJYP，将其化学成分之一（HCT）用作内标，以确定其他两种活性成分的含量。最后，建立了红外指纹图谱和HPLC指纹图谱，以综合评价ZHJYP的质量一致性。结果表明，建立的红外定量模型在预测活性成分含量方面具有较好的性能。此外，通过QAMS方法和外标方法（ESM）计算的两种成分的含量之间没有显着差异。综上所述，两种活性成分分析方法与指纹图谱分析相结合，将为活性化合物的分析和ZHJYP的总体质量控制提供有价值的参考。