Posttraumatic stress disorder (PTSD) is the most prevalent type of psychiatric disorder among children after an earthquake. This study investigated the role of trauma experiences, personality traits, and genotype in the maintenance of PTSD symptoms. In a previous large-scale epidemiological investigation 1 year after the Wenchuan earthquake, 215 children with PTSD symptoms were selected at random with their blood samples collected. All of them were followed up, and their PTSD symptoms were assessed 3 years later. The adolescent version of the UCLA PTSD Reaction Index, the earthquake exposure scale, and the Junior Eysenck Personality Questionnaire were used to determine PTSD symptoms, trauma experiences, and personality traits, respectively. We sequenced candidate genes involved in the regulation of long-term potentiation via NMDA-type receptors to identify the related SNP variations. Being trapped for a longer period of time, feeling one’s own or a family member’s life to be in danger, losing a close family member or friend, extraversion, neuroticism, TrkB, G72 and CNTF were found to be associated with the maintenance of PTSD symptoms. Experiences, personality traits, and genotype influenced the maintenance of PTSD in child survivors who were considered to be followed up without medicine. This result could help to identify potential targets for treatment and promote the rational allocation of medical resources.

中文翻译：

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创伤经历，人格特质和基因型在维持汶川地震儿童幸存者创伤后应激障碍症状中的作用。

创伤后应激障碍（PTSD）是地震后儿童中最普遍的精神疾病。这项研究调查了创伤经历，人格特质和基因型在维持PTSD症状中的作用。在汶川地震发生1年后的一次大规模流行病学调查中，随机抽取了215名患有PTSD症状的儿童并收集了他们的血液样本。他们都进行了随访，并在3年​​后评估了他们的PTSD症状。青年版的UCLA PTSD反应指数，地震暴露量表和少年艾森克人格问卷分别用于确定PTSD症状，创伤经历和人格特质。我们通过NMDA型受体对参与长期增强调控的候选基因进行了测序，以鉴定相关的SNP变异。被发现被困时间较长，感觉自己或家人的生命处于危险之中，失去亲密的家人或朋友，外向，神经质，TrkB，G72和CNTF与维持PTSD症状有关。经验，人格特质和基因型影响了儿童幸存者PTSD的维持，这些幸存者被认为无需药物治疗。该结果可能有助于确定潜在的治疗目标，并促进医疗资源的合理分配。失去亲密的家人或朋友，外向性，神经质，TrkB，G72和CNTF与维持PTSD症状有关。经验，人格特质和基因型影响了儿童幸存者PTSD的维持，这些幸存者被认为无需药物治疗。该结果可能有助于确定潜在的治疗目标，并促进医疗资源的合理分配。失去亲密的家人或朋友，外向性，神经质，TrkB，G72和CNTF与维持PTSD症状有关。经验，人格特质和基因型影响了儿童幸存者PTSD的维持，这些幸存者被认为无需药物治疗。该结果可能有助于确定潜在的治疗目标，并促进医疗资源的合理分配。