Due to their low cost and excellent solubility, functional ionic liquids (ILs) have been widely used in the pretreatment of lignocellulose. However, the high viscosity and harsh pretreatment conditions of ILs usually bring difficulties in separation and regeneration, hindering the large-scale use of ILs for industrial applications. To solve these problems, four sugar-platform renewable high boiling alcohol solvents (HBS) that can form hydrogen bonds with lignin were chosen as co-solvents. This confirmed that HBS not only have an effect on the interaction of ILs and lignin, but they also participate in the interaction of the co-solvent and lignin. The cation–anion interaction energy in 2-hydroxy-N-(2-hydroxyethyl)-N-methylethanaminium methanesulfonate ([BHEM]mesy) is weakened, but for hydrogen bond interactions, like IL-lignin and co-solvent-lignin, the energy is increased, as shown by a series of characterization and analysis studies. The system has advantages, like mild reaction conditions, low cost, renewability, high biomass pretreatment efficiency, and excellent cycling performance, which can increase the lignin removal ratio to 95.2%. The recycling and reusability were also evaluated and, after seven rounds, there was no significant reduction in activity. This work provides a promising large-scale sustainable biomass pretreatment strategy for biorefinery processes.

中文翻译：

---

通过增加氢键总数来促进选择性去除木质素的可再生助溶剂

由于它们的低成本和优异的溶解性，功能性离子液体（ILs）已广泛用于木质纤维素的预处理。然而，IL的高粘度和苛刻的预处理条件通常给分离和再生带来困难，从而阻碍了IL在工业应用中的大规模使用。为了解决这些问题，选择了四种可以与木质素形成氢键的糖平台可再生高沸点醇溶剂（HBS）作为助溶剂。这证实了HBS不仅影响IL与木质素的相互作用，而且还参与助溶剂与木质素的相互作用。2-羟基-N-（2-羟基乙基）-N中的阳离子-阴离子相互作用能-甲基乙磺酸甲烷磺酸盐（[BHEM] mesy）被削弱，但是对于氢键相互作用，如IL-木质素和助溶剂-木质素，能量增加，如一系列表征和分析研究所示。该系统具有反应条件温和，成本低，可更新性，生物质预处理效率高，循环性能优异等优点，可将木质素去除率提高到95.2％。还评估了回收利用和可重复使用性，经过七个回合后，活动没有明显减少。这项工作为生物精炼过程提供了一种有前途的大规模可持续生物质预处理策略。