Transient receptor potential (TRP) proteins consist of a superfamily of cation channels that have been involved in diverse physiological processes in the brain as well as in the pathogenesis of neurological disease. TRP channels are widely expressed in the brain, including neurons and glial cells, as well as in the cerebral vascular endothelium and smooth muscle. Members of this channel superfamily show a wide variety of mechanisms ranging from ligand binding to voltage, physical, and chemical stimuli, implying the promising therapeutic potential of TRP in neurological diseases. In this review, we focus on the physiological functions of TRP channels in the brain and the pathological roles in neurological disorders to explore future potential neuroprotective strategies.

中文翻译：

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TRP通道在神经系统疾病中的作用。

瞬态受体电位（TRP）蛋白由阳离子通道的超家族组成，阳离子通道已参与大脑中各种生理过程以及神经系统疾病的发病机制。TRP通道在脑中广泛表达，包括神经元和神经胶质细胞，以及在脑血管内皮和平滑肌中。该通道超家族的成员显示出广泛的机制，从配体结合到电压，物理和化学刺激，暗示着TRP在神经疾病中的治疗潜力。在这篇综述中，我们专注于大脑中TRP通道的生理功能以及神经系统疾病的病理作用，以探索未来潜在的神经保护策略。