Astroviruses (AstVs) cause disease in a wide variety of species. Porcine AstVs are highly genetically diverse and conventionally assigned to five genetic lineages (PoAstV1-5). Due to the increasing evidence that porcine astrovirus type 3 (PoAstV3) is a cause of encephalomyelitis in swine and to elucidate important ecologic characteristics, the infection dynamics and environmental distribution of PoAstV3 were investigated in a herd with PoAstV3-associated neurologic disease. Over a 22 week period, the frequency of PoAstV3 fecal shedding varied by pig and age. The peak detection by RT-qPCR of PoAstV3 on fecal swabs (95%; 61 of 64) occurred at 3 weeks of age. The lowest frequency of detection was at 21 weeks of age (4%; 2 of 47); however, the frequency increased to 41% (19 of 46) at the final sampling time point (25 weeks of age). Viremia was rare (0.9%: 4 of 433). Detection in oral fluid was consistent with 75% to 100% of samples positive at each time point. Pens and feeders also had a high rate of detection with a majority of samples positive at a majority of sampling time points. Based on the data presented, PoAstV3 can be consistently detected in the environment with a majority of pigs being infected and a subset intermittently shedding the virus in feces out to 25 weeks of age. These findings suggest the importance of as-yet unidentified risk factors associated with the development of PoAstV3-associated polioencephalomyelitis.

中文翻译：

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伴有相关神经疾病的猪群中3型猪星状病毒的生态学。

星状病毒（AstVs）导致多种疾病。猪的AstV具有高度的遗传多样性，并且通常分配给五个遗传谱系（PoAstV1-5）。由于越来越多的证据表明3型猪星状病毒（PoAstV3）是猪脑脊髓炎的病因，并且为了阐明重要的生态学特征，在与PoAstV3相关的神经疾病群中调查了PoAstV3的感染动态和环境分布。在22周内，PoAstV3粪便脱落的频率因猪和年龄而异。通过RT-qPCR在粪便拭子上检测PoAstV3的峰值（95％； 64个样本中的61个）出现在3周龄时。最低的检测频率是21周龄（4％； 47个中的2个）；但是，在最终采样时间点（25周龄），频率增加到41％（46个中的19个）。病毒血症很罕见（0。9％：433之4）。在每个时间点，口腔液中的检测结果与阳性样本的75％至100％一致。笔和进纸器的检出率也很高，大多数样品在大多数采样时间点均为阳性。根据提供的数据，PoAstV3可以在环境中被一致地检测到，大多数猪都被感染了，并且有一个子集在25周龄时间歇性地在粪便中排出病毒。这些发现表明，与PoAstV3相关的脊髓灰质脑脊髓炎的发展相关的尚未确定的危险因素的重要性。PoAstV3可以在环境中被一致地检测到，大多数猪都被感染了，并且有一个子集间歇性地将该病毒排出到25周龄的粪便中。这些发现表明，与PoAstV3相关的脊髓灰质脑脊髓炎的发展相关的尚未确定的危险因素的重要性。PoAstV3可以在环境中被一致地检测到，大多数猪都被感染了，并且有一个子集间歇性地将该病毒排出到25周龄的粪便中。这些发现表明，与PoAstV3相关的脊髓灰质脑脊髓炎的发展相关的尚未确定的危险因素的重要性。