Nanoparticle-based drug delivery systems for cancer therapy offer a great promising opportunity as they specifically target cancer cells, also increasing the bioavailability of anticancer drugs characterized by low water solubility. Platicur, [Pt(cur) (NH₃)₂](NO₃), is a cis-diamine–platinum(II) complex linked to curcumin. In this work, an ultrasonication method, coupled with layer by layer technology, allows us to obtain highly aqueous stable Platicur nanocolloids of about 100 nm. The visible light-activated Platicur nanocolloids showed an increased drug release and antitumor activity on HeLa cells, with respect to Platicur nanocolloids in darkness. This occurrence could give very interesting insight into selective activation of the nanodelivered Pt(II) complex and possible side-effect lowering. For the first time, the metabolic effects of Platicur nanocolloid photoactivation, in the HeLa cell line, have been investigated using an NMR-based metabolomics approach coupled with statistical multivariate data analysis. The reported results highlight specific metabolic differences between photoactivated and non-photoactivated Platicur NC-treated HeLa cancer cells.

中文翻译：

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可见光活化水溶性 Platicur 纳米胶体：癌细胞的光细胞毒性和代谢组学研究

用于癌症治疗的基于纳米颗粒的药物递送系统提供了一个非常有前途的机会，因为它们专门针对癌细胞，还增加了以低水溶性为特征的抗癌药物的生物利用度。Platicur，[Pt(cur) (NH ₃ ) ₂ ](NO ₃ )，是顺式-二胺-铂（II）复合物与姜黄素相连。在这项工作中，超声波处理方法与逐层技术相结合，使我们能够获得约 100 nm 的高度水性稳定的 Platicur 纳米胶体。与黑暗中的 Platicur 纳米胶体相比，可见光激活的 Platicur 纳米胶体对 HeLa 细胞的药物释放和抗肿瘤活性增加。这种情况可以为纳米递送的 Pt(II) 复合物的选择性激活和可能的副作用降低提供非常有趣的见解。首次使用基于 NMR 的代谢组学方法结合统计多元数据分析研究了 Platicur 纳米胶体光活化在 HeLa 细胞系中的代谢效应。