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Comparative pharmacokinetics of Ding‐Zhi‐Xiao‐Wan preparation and its single herbs in rats by using a putative multiple‐reaction monitoring UPLC‐MS/MS method
Phytochemical Analysis ( IF 3.3 ) Pub Date : 2020-09-07 , DOI: 10.1002/pca.2982
Yufei Sun 1, 2 , Yang He 3 , Shuxin Liu 1, 2 , Hongxue Gao 1, 2 , Zifeng Pi 1 , Fengrui Song 1 , Zhiqiang Liu 1, 2 , Shu Liu 1
Affiliation  

The formula of Chinese medicine, Ding‐Zhi‐Xiao‐Wan (DZXW), has the distinct feature of compatibility therapy, which is attributed to the interactions of multi‐herbs. However, the quantification problem caused by the absence of pure reference standards is a bottleneck to clarify the compatibility advantages from the perspective of pharmacokinetics (PKs).

中文翻译:

推定的多反应监测UPLC-MS / MS方法比较定智小丸制剂及其单药在大鼠中的药代动力学

中药配方定智小丸(DZXXW)具有相容性治疗的独特功能,这归因于多种草药的相互作用。但是,由于缺乏纯参考标准品而导致的量化问题是从药代动力学(PKs)角度阐明相容性优势的瓶颈。
更新日期:2020-09-07
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