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Characterization of tryptophan-containing dipeptides for anti-angiogenic effects.
Acta Physiologica ( IF 6.3 ) Pub Date : 2020-09-07 , DOI: 10.1111/apha.13556
Sherif Khedr 1, 2 , Anne Klotzsche-von Ameln 1 , Maha Khedr 3, 4 , Mohamed H Elsayed 2 , Thangirala Sudha 3 , Shaker A Mousa 3 , Andreas Deussen 1 , Melanie Martin 1
Affiliation  

In the pathogenesis of several diseases, neo‐angiogenesis is increased (e.g. tumour growth). The peptide L‐glutamyl‐L‐tryptophan (EW/IM862) has been claimed to exhibit inhibitory effects on tumour growth in vivo. However, the potential role of natural peptides with respect to anti‐angiogenic properties is unsettled. The current study explores anti‐angiogenic effects of the dipeptides WL, EW, IW and WE.

中文翻译:

含有色氨酸的二肽具有抗血管生成作用的表征。

在几种疾病的发病机制中,新血管生成增加(例如肿瘤生长)。肽 L-谷氨酰-L-色氨酸 (EW/IM862) 据称对体内肿瘤生长具有抑制作用。然而,天然肽在抗血管生成特性方面的潜在作用尚未确定。目前的研究探索了二肽 WL、EW、IW 和 WE 的抗血管生成作用。
更新日期:2020-09-07
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