Childhood onset chronic inflammatory demyelinating polyneuropathy (CIDP) often requires long‐term immunomodulatory therapy. We report a comprehensive review of our treatment of pediatric CIDP with a focus on high‐dose weekly corticosteroids (“pulse oral corticosteroids”), a treatment method that is not commonly reported. We retrospectively reviewed medical records of pediatric patients with CIDP treated at our center between 2000 and 2018 for whom we had at least 12 mo follow‐up. Here, we describe the demographics, disease course, treatment regimens, and long‐term outcomes of these patients. Twenty‐five patients were identified for analysis. Pulse oral corticosteroid monotherapy was the predominant maintenance treatment in 56% of patients. Patients were followed for a median of 4 y. Side effects were seen in a minority of patients. The probability of a normal exam or being off treatment at last follow‐up was similar regardless of predominant maintenance therapy. Pulse oral corticosteroid therapy is a safe and effective long‐term treatment option in children with CIDP.

中文翻译：

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小儿慢性炎症性脱髓鞘性多发性神经病的脉搏口服糖皮质激素。

儿童期发作的慢性炎症性脱髓鞘性多发性神经病（CIDP）通常需要长期的免疫调节治疗。我们报告了对小儿CIDP治疗的全面回顾，重点是每周大剂量使用皮质类固醇（“脉冲口服皮质类固醇”），这种治疗方法并不常见。我们回顾性研究了2000年至2018年间在我们中心接受治疗的CIDP小儿患者的病历，这些患者至少进行了12个月的随访。在这里，我们描述了这些患者的人口统计学，疾病历程，治疗方案和长期结果。确定了25例患者进行分析。脉冲口服皮质类固醇单药治疗是56％患者的主要维持治疗。随访患者的中位数为4年。在少数患者中发现了副作用。不管采用哪种主要的维持治疗方法，正常检查或在最后一次随访中退出治疗的可能性都相似。脉冲口服糖皮质激素治疗对CIDP儿童是一种安全有效的长期治疗选择。