Individuals can use diverse behavioral strategies to navigate their environment including hippocampal‐dependent place strategies reliant upon cognitive maps and striatal‐dependent response strategies reliant upon egocentric body turns. The existence of multiple memory systems appears to facilitate successful navigation across a wide range of environmental and physiological conditions. The mechanisms by which these systems interact to ultimately generate a unitary behavioral response, however, remain unclear. We trained 20 male, Sprague–Dawley rats on a dual‐solution T‐maze while simultaneously recording local field potentials that were targeted to the dorsolateral striatum and dorsal hippocampus. Eight rats spontaneously exhibited a place strategy while the remaining 12 rats exhibited a response strategy. Interindividual differences in behavioral strategy were associated with distinct patterns of LFP activity between the dorsolateral striatum and dorsal hippocampus. Specifically, striatal‐hippocampal theta activity was in‐phase in response rats and out‐of‐phase in place rats and response rats exhibited elevated striatal‐hippocampal coherence across a wide range of frequency bands. These contrasting striatal‐hippocampal activity regimes were (a) present during both maze‐learning and a 30 min premaze habituation period and (b) could be used to train support vector machines to reliably predict behavioral strategy. Distinct patterns of neuronal activity across multiple memory systems, therefore, appear to bias behavioral strategy selection and thereby contribute to interindividual differences in behavior.

中文翻译：

---

记忆系统局部场电位活动的个体差异预测双解 T 迷宫的行为策略。

个人可以使用不同的行为策略来驾驭他们的环境，包括依赖于认知地图的海马依赖位置策略和依赖于以自我为中心的身体转动的纹状体依赖反应策略。多个记忆系统的存在似乎有助于在广泛的环境和生理条件下成功导航。然而，这些系统相互作用以最终产生单一行为反应的机制仍不清楚。我们在双溶液 T 迷宫上训练了 20 只雄性 Sprague-Dawley 大鼠，同时记录了针对背外侧纹状体和背海马体的局部场电位。八只大鼠自发地表现出放置策略，而其余 12 只大鼠表现出反应策略。行为策略的个体差异与背外侧纹状体和背海马体之间 LFP 活动的不同模式有关。具体而言，纹状体 - 海马的 theta 活动在响应大鼠中是同相的，而在原位大鼠和响应大鼠中表现出较高的纹状体 - 海马相干性在很宽的频带范围内。这些对比鲜明的纹状体 - 海马活动机制（a）在迷宫学习和 30 分钟的迷宫前适应期都存在，（b）可用于训练支持向量机以可靠地预测行为策略。因此，跨多个记忆系统的不同神经元活动模式似乎会偏向行为策略选择，从而导致行为的个体差异。