Objective

Circulating levels of fibroblast growth factor 21 (FGF21) increase with advancing age and may lead to the development of cardiometabolic diseases via impaired lipid and glucose metabolism. While physical activity can reduce these risks of cardiometabolic dysfunction, it remains obscure whether circulation FGF21 levels are influenced by physical activity. The purpose of this study was to investigate the relations between daily physical activities and circulating FGF21 levels in middle-aged and older adults.

Methods

In this cross-sectional study with 110 middle-aged and 102 older adults, circulating (serum) FGF21 levels were evaluated by enzyme-linked immunosorbent assay, and the time spent in light-intensity physical activity (LPA) and moderate-to-vigorous-intensity physical activity (MVPA) was assessed using a uniaxial accelerometer.

Results

Serum FGF21 levels in the older group (158 pg/mL) were significantly higher than those in the middle-aged group (117 pg/mL). When we examined the joint association of age (middle-aged or older) and MVPA (lower or higher than the median) groups, serum FGF21 levels in the older and higher MVPA group (116 pg/mL) were significantly lower than those in the older and lower MVPA group (176 pg/mL). However, there was no difference in serum FGF21 levels between the lower and higher MVPA groups in the middle-aged group. In multivariable liner regression analysis, serum FGF21 levels were independently determined by MVPA time after adjusting for potential covariates in older adults (β = −0.209).

Conclusions

These cross-sectional study findings indicate that the time spent in MVPA is an independent determinant of circulating FGF21 levels, and that an age-related increase in serum FGF21 levels may be attenuated by habitually performing MVPA. (250/250 words).

中文翻译：

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中老年人体力活动与循环成纤维细胞生长因子 21 的关系。

客观的

成纤维细胞生长因子 21 (FGF21) 的循环水平随着年龄的增长而增加，并可能通过脂质和葡萄糖代谢受损导致心脏代谢疾病的发展。虽然体育活动可以降低心脏代谢功能障碍的这些风险，但循环 FGF21 水平是否受体育活动影响仍不清楚。本研究的目的是调查中老年人日常体力活动与循环 FGF21 水平之间的关系。

方法

在这项针对 110 名中年和 102 名老年人的横断面研究中，通过酶联免疫吸附试验评估循环（血清）FGF21 水平，以及在光强度体力活动 (LPA) 和中到剧烈运动中花费的时间-使用单轴加速度计评估强度身体活动（MVPA）。

结果

老年组血清 FGF21 水平 (158 pg/mL) 显着高于中年组 (117 pg/mL)。当我们检查年龄（中年或以上）和 MVPA（低于或高于中位数）组的联合关联时，年龄较大和较高 MVPA 组（116 pg/mL）的血清 FGF21 水平显着低于年龄较大和较低的 MVPA 组 (176 pg/mL)。然而，中年组中低和高MVPA组的血清FGF21水平没有差异。在多变量线性回归分析中，血清 FGF21 水平在调整老年人的潜在协变量后由 MVPA 时间独立确定（β  = -0.209）。

结论

这些横断面研究结果表明，在 MVPA 中花费的时间是循环 FGF21 水平的独立决定因素，并且与年龄相关的血清 FGF21 水平升高可能会因习惯性进行 MVPA 而减弱。（250/250 字）。