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Fabrication of functionalized layered double hydroxide/chitosan nanocomposite with dual responsive drug release for the targeted therapy of breast cancer
European Polymer Journal ( IF 6 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.eurpolymj.2020.109993
T.S. Anirudhan , V. Chithra Sekhar

Abstract The DDS based on isocyanato functionalized layered double hydroxide (LDH-NCO), folic acid conjugated thiolated chitosan (TCS) and gold nanoparticle (AuNp) was used for actively targeted chemophotothermal therapy of breast cancer. The LDH-NCO was conjugated to TCS and forming LDH-NCO-TCS composite. The AuNp are appended on the surface of the LDH-NCO-TCS by electrostatic and soft acid soft base interaction and LDH-NCO-TCS/AuNp nanocomposite was formed. Doxorubicin (DOX) was loaded in LDH-NCO-TCS/AuNp through hydrogen bonding and static interactions. The presence of AuNps withstands high temperature by the near-infrared (NIR) light irradiation, which enhances the photothermal therapy. Besides stimuli responsive drug release was studied at two pHs 5.5 and 7.4. Toxicity studies of DOX loaded LDH-NCO-TCS/AuNp were carried out using breast cancer (MCF7) cells. Blood compatibility studies show the negligible haemolytic activity of the carrier. Flow cytometry analysis showed the significant cell death in G0/G1 phase after treatment with DOX loaded LDH-NCO-TCS/AuNp.

中文翻译:

具有双重响应药物释放的功能化层状双氢氧化物/壳聚糖纳米复合材料用于乳腺癌靶向治疗的制备

摘要 基于异氰酸酯官能化层状双氢氧化物 (LDH-NCO)、叶酸偶联硫醇化壳聚糖 (TCS) 和金纳米颗粒 (AuNp) 的 DDS 用于乳腺癌的主动靶向化学光热治疗。LDH-NCO 与 TCS 结合形成 LDH-NCO-TCS 复合材料。AuNp通过静电和软酸软碱相互作用附着在LDH-NCO-TCS表面,形成LDH-NCO-TCS/AuNp纳米复合材料。通过氢键和静态相互作用将阿霉素 (DOX) 加载到 LDH-NCO-TCS/AuNp 中。AuNps 的存在通过近红外 (NIR) 光照射承受高温,从而增强了光热疗法。除了刺激响应性药物释放外,还研究了两种 pH 值 5.5 和 7.4。使用乳腺癌 (MCF7) 细胞进行了加载 DOX 的 LDH-NCO-TCS/AuNp 的毒性研究。血液相容性研究表明载体的溶血活性可以忽略不计。流式细胞术分析显示,在用负载 DOX 的 LDH-NCO-TCS/AuNp 处理后,G0/G1 期细胞明显死亡。
更新日期:2020-10-01
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