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Blood Biochemical and Erythrocytic Morpho-pathological Consequences of Naphthalene Intoxication in Indian Teleost, Anabas testudineus (Bloch).
Environmental Toxicology and Pharmacology ( IF 4.3 ) Pub Date : 2020-09-07 , DOI: 10.1016/j.etap.2020.103490
Sukhendu Dey 1 , Puspita Ballav 1 , Arghya Mandal 1 , Palas Samanta 2 , Atanu Patra 1 , Subhas Das 1 , Arnab Kumar Mondal 1 , Apurba Ratan Ghosh 1
Affiliation  

Anabas testudineus (Bloch) was exposed to 0.71 mg/L and 1.42 mg/L (25 and 50% of LC50 value respectively) naphthalene, a polycyclic aromatic hydrocarbon (PAH), for 21 days. Blood biochemical parameters and erythrocytic morphological alterations were assessed to describe the naphthalene toxicity. Biochemical analysis showed a significant increase in glutamic pyruvic transaminase, GPT (576.7 ± 11.79 and 608.9 ± 12.08 U/L, respectively) and alkaline phosphatase, ALP (12.9 ± 0.69 and 13.4 ± 0.64 U/L, respectively) activities under two doses compared with control. Protein and albumin (ALB) content in blood decreased significantly, in comparison with control value in the tune of 22.67 ± 1.04 and 23.97 ± 1.24 g/dl, respectively and 10.7 ± 0.79 and 11.1 ± 0.67 g/dl, respectively. Erythrocytes showed varied symptomatic morphological changes under naphthalene exposure, which included severe denaturation, swelling in cells, appearance of sickle and tear drop cells, and cellular vacuolation. In particularly, the changes were more prominent under higher naphthalene exposure. Following the results, it has been able to establish that GPT, ALP, protein and ALB, and the morphological manifestations of erythrocytes would be good tools of biomarker in monitoring toxicological paradigm, especially to naphthalene exposure in aquatic bodies.



中文翻译:

印度硬骨鱼Anastas testudineus(Bloch)中萘中毒的血液生化和红细胞形态病理后果。

将Anabas testudineus(Bloch)暴露于0.71 mg / L和1.42 mg / L(25和50%的LC 50分别是多环芳烃(PAH)萘21天。评估血液生化参数和红细胞形态改变以描述萘的毒性。生化分析表明,两种剂量下的谷氨酸丙酮酸转氨酶,GPT(分别为576.7±11.79和608.9±12.08 U / L)和碱性磷酸酶,ALP(分别为12.9±0.69和13.4±0.64 U / L)显着增加。与控制。与对照组相比,血液中的蛋白质和白蛋白(ALB)含量显着降低,分别为22.67±1.04和23.97±1.24 g / dl,分别为10.7±0.79和11.1±0.67 g / dl。在萘暴露下,红细胞表现出各种症状形态变化,包括严重变性,细胞肿胀,镰刀和泪滴细胞的出现,以及细胞空泡化。特别是在较高的萘暴露下,变化更为明显。根据结果​​,可以确定GPT,ALP,蛋白质和ALB以及红细胞的形态学表现将是监测毒理学范式(尤其是萘在水生生物中)的生物标志物的良好工具。

更新日期:2020-09-24
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