Immuno-castration is increasingly recommended in pigs due to welfare reasons; however, there are few studies in females compared to males. This aim of this study was to investigate the effects of immuno-castration in female and male pigs. The weight, the morphometric and microscopic characteristics of the reproductive organs, and the hormone concentrations were studied in 12 immunocastrated females (IF) and 12 immunocastrated males (IM) and compared with control animals (C). At slaughter, IF tended to have greater body weights than CF (P = 0.051), whereas in IM and CM pigs there were not body weight differences (P = 0.140). The weight of the reproductive tract and size of all individual organs were less in IF compared with CF. Results from histological assessments indicated IF had more atretic follicles and a thinner endometrial mucosa than control females. Hormone concentrations were not different between CF and IF (P > 0.050). As a result of immuno-castration, there was impaired spermatogenesis in most males. Results from microscopic evaluations indicated there was a marked decrease of spermatogonial cells and size of Leydig cells in the testicles. Accessory gland structures were affected in CM and IM with there being differences in gross and microscopic characteristics. Testosterone concentrations, unlike estradiol, were different in IM compared to CM (P < 0.001). These results provide evidence that immuno-castration with the anti-gonadotrophin releasing hormone vaccine is effective in female and male pigs and induces morphological and endocrine changes incompatible with fertility.

由于福利原因，越来越多地建议对猪进行免疫阉割；然而，与男性相比，女性的研究很少。本研究的目的是研究免疫阉割对雌性和雄性猪的影响。研究了 12 只免疫去势雌性 (IF) 和 12 只免疫去势雄性 (IM) 的体重、生殖器官的形态测量和微观特征以及激素浓度，并与对照动物 (C) 进行了比较。在屠宰时，IF 往往比 CF 具有更大的体重（P  = 0.051），而在 IM 和 CM 猪中，体重没有差异（P = 0.140）。与 CF 相比，IF 中生殖道的重量和所有单个器官的大小都较小。组织学评估结果表明 IF 比对照女性有更多的闭锁卵泡和更薄的子宫内膜粘膜。CF 和 IF 之间的激素浓度没有差异（P  > 0.050）。由于免疫阉割，大多数男性的精子发生受损。显微镜评估的结果表明睾丸中的精原细胞和 Leydig 细胞的大小显着减少。CM 和 IM 的附属腺体结构受到影响，在大体和微观特征上存在差异。与雌二醇不同，IM 中的睾酮浓度与 CM 不同（P < 0.001)。这些结果提供了证据，证明使用抗促性腺激素释放激素疫苗进行免疫阉割对雌性和雄性猪有效，并诱导与生育能力不相容的形态学和内分泌变化。