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Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment.
Pharmaceutical Research ( IF 3.7 ) Pub Date : 2020-09-07 , DOI: 10.1007/s11095-020-02917-6
Gabriela Corrêa Carvalho 1 , Rafael Miguel Sábio 1 , Tais de Cássia Ribeiro 1 , Andreia Sofia Monteiro 2 , Daniela Vassalo Pereira 2 , Sidney José Lima Ribeiro 2 , Marlus Chorilli 1
Affiliation  

Infectious diseases are a major global concern being responsible for high morbidity and mortality mainly due to the development and enhancement of multidrug-resistant microorganisms exposing the fragility of medicines and vaccines commonly used to these treatments. Taking into account the scarcity of effective formulation to treat infectious diseases, nanotechnology offers a vast possibility of ground-breaking platforms to design new treatment through smart nanostructures for drug delivery purposes. Among the available nanosystems, mesoporous silica nanoparticles (MSNs) stand out due their multifunctionality, biocompatibility and tunable properties make them emerging and actual nanocarriers for specific and controlled drug release. Considering the high demand for diseases prevention and treatment, this review exploits the MSNs fabrication and their behavior in biological media besides highlighting the most of strategies to explore the wide MSNs functionality as engineered, smart and effective controlled drug release nanovehicles for infectious diseases treatment.



中文翻译:

介孔二氧化硅纳米颗粒作为用于传染病治疗的多功能控制的药物输送纳米平台的亮点。

传染病是引起高发病率和高死亡率的全球主要关注点,这主要归因于多药耐药性微生物的发展和增强,暴露了通常用于这些治疗的药物和疫苗的脆弱性。考虑到缺乏有效的配方来治疗传染性疾病,纳米技术提供了开创性平台的巨大可能性,可以通过智能纳米结构为药物输送目的设计新的治疗方法。在可用的纳米系统中,介孔二氧化硅纳米粒子(MSN)脱颖而出,因为它们的多功能性,生物相容性和可调性使其成为新兴的和实际的纳米载体,可用于特定和受控的药物释放。考虑到对疾病预防和治疗的高度需求,

更新日期:2020-09-08
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