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Application and clinical impact of the RESIST-4 O.K.N.V. rapid diagnostic test for carbapenemase detection in blood cultures and clinical samples.
European Journal of Clinical Microbiology & Infectious Diseases ( IF 4.5 ) Pub Date : 2020-09-07 , DOI: 10.1007/s10096-020-04021-4
Sophie Roth 1 , Fabian K Berger 1 , Andreas Link 2 , Anna Nimmesgern 1 , Philipp M Lepper 3 , Niels Murawski 4 , Jörg T Bittenbring 4 , Sören L Becker 1
Affiliation  

Invasive infections caused by carbapenemase-producing bacteria are associated with excess mortality. We applied a rapid diagnostic test (RDT) on clinical samples with an elevated likelihood of carbapenemase-producing bacteria and documented its impact on antibiotic treatment decisions. Among 38 patients, twelve tested positive for infections caused by carbapenemase-producing bacteria (31.6%), mainly in blood cultures. KPC (n = 10) was more frequent than OXA-48 (n = 2). RDT-based carbapenemase detection led to a treatment modification to ceftazidime/avibactam-containing regimens in all patients before detailed antibiotic testing results became available. Eleven patients (92%) survived the acute infection, whereas one patient with a ceftazidime/avibactam- and colistin-resistant OXA-48-positive isolate died.



中文翻译:

RESIST-4 OKNV 快速诊断测试在血培养和临床样本中检测碳青霉烯酶的应用和临床影响。

由产生碳青霉烯酶的细菌引起的侵袭性感染与死亡率过高有关。我们对产生碳青霉烯酶的细菌可能性较高的临床样本进行了快速诊断测试 (RDT),并记录了其对抗生素治疗决策的影响。在 38 名患者中,有 12 人检测出由产碳青霉烯酶细菌引起的感染呈阳性(31.6%),主要是在血培养中。KPC ( n = 10) 比 OXA-48 ( n  = 2) 更常见。在获得详细的抗生素检测结果之前,基于 RDT 的碳青霉烯酶检测导致所有患者对含头孢他啶/阿维巴坦的治疗方案进行了治疗修改。11 名患者 (92%) 在急性感染中幸存,而一名头孢他啶/阿维巴坦和粘菌素耐药 OXA-48 阳性分离株患者死亡。

更新日期:2020-09-08
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